Results 21 to 30 of about 24,725 (157)

Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]

American Journal of Ophthalmology, 2018
To review the pathogenesis of uveitis in light of recent advances in our understanding of innate and adaptive immune responses and their regulation.Perspective.Methods included a review of prevailing views on the pathogenesis of uveitis and an analysis of developments in immunology that impact on its conceptual basis, particularly the concept of ...
John V. Forrester, Lucia Kuffova, Andrew D. Dick   +2 more
openaire   +5 more sources

Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency. [PDF]

J Exp Med
The last decades have brought a rapid expansion of the number of primary disorders related to the polyubiquitination pathways in humans. Most of these disorders manifest with two seemingly contradictory clinical phenotypes: autoinflammation ...
Spaan AN, Boisson B, Masters SL.
europepmc   +2 more sources

Imaging of Joints and Bones in Autoinflammation [PDF]

Journal of Clinical Medicine, 2020
Autoinflammatory disorders are commonly characterized by seemingly unprovoked systemic inflammation mainly driven by cells and cytokines of the innate immune system. In many disorders on this spectrum, joint and bone involvement may be observed and imaging of these manifestations can provide essential diagnostic information.
Katharina Ziegeler, Iris Eshed, Torsten Diekhoff, Kay Geert Hermann   +3 more
openaire   +2 more sources

Autoinflammation: From monogenic syndromes to common skin diseases [PDF]

, 2013
Autoinflammation is characterized by aberrant regulation of the innate immune system and often manifests as periodic fevers and systemic inflammation involving multiple organs, including the skin. Mutations leading to abnormal behavior or activity of the
Nguyen, Tien V, Tien V. Nguyen, Edward W. Cowen, Leslie, Kieron S, Kieron S. Leslie, Cowen, Edward W   +5 more
core   +1 more source

Gene hunting in autoinflammation

Clinical and Translational Allergy, 2013
AbstractSteady progress in our understanding of the genetic basis of autoinflammatory diseases has been made over the past 16 years. Since the discovery of the familial Me diterranean f ev er gene MEFV (also known as marenostrin) in 1997, 18 other genes responsible for monogenic autoinflammatory diseases have been identified to date.
Standing, Ariane, Omoyinmi, Ebun, Brogan, Paul   +2 more
openaire   +2 more sources

The burgeoning field of innate immune-mediated disease and autoinflammation. [PDF]

, 2017
Immune-mediated autoinflammatory diseases are occupying an increasingly prominent position among the pantheon of debilitating conditions that afflict mankind.
Scambler, T, McDermott, MF, Savic, S, Peckham, D   +3 more
core   +1 more source

Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases

, 2021
Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory diseases) and autoimmune diseases (such as systemic lupus erythematosus and ...
Szekanecz, Zoltán, Szűcs, Gabriella, Schett, Georg, Szamosi, Szilvia, McInnes, Iain B., Benkő, Szilvia   +5 more
core   +1 more source

Inflammation, Autoinflammation and Autoimmunity in Inflammatory Bowel Diseases [PDF]

, 2023
In this review, the role of innate and adaptive immunity in the pathogenesis of inflammatory bowel diseases (IBD) is reported. In IBD, an altered innate immunity is often found, with increased Th17 and decreased Treg cells infiltrating the intestinal ...
Giulia Musso, Nicole Contran, Andrea Padoan, Daniela Basso   +3 more
core   +1 more source

Adult-onset autoinflammation caused by somatic mutations in UBA1:A Dutch case series of patients with VEXAS [PDF]

, 2022
Background: A novel autoinflammatory syndrome was recently described in male patients who harbored somatic mutations in the X-chromosomal UBA1 gene. These patients were characterized by adult-onset, treatment-refractory inflammation with fever, cytopenia,
Heijstek, Marloes, Beck, David B., van der Made, C.I., van de Veerdonk, F.L., Kwakernaak, A J, van Paassen, Pieter, van Gijn, Marielle E., Beck, David B, Kwakernaak, A.J., van der Made, Caspar I., Kwakernaak, Arjan J., Leavis, Helen L., Hak, A E, Rutgers, A., Hoogstins, Annemiek, Simons, Annet, Netea, M.G., Elizabeth Hak, A., van der Veken, Lars T, van de Veerdonk, Frank L., Willems, Huub P J, van Gijn, Marielle E, van Paassen, P., Rutgers, Abraham; id_orcid, Netea, Mihai G, van Gijn, M.E., Leavis, Helen L, Potjewijd, J., Hoischen, Alexander, Heijstek, M., Willems, Huub P.J., de Sevaux, Ruud G L, van der Made, Caspar I, Rutgers, Abraham, de Sevaux, R.G.L., Beck, D.B., van Daele, Paul L.A., van Daele, Paul L A, van der Veken, Lars T., Hoogstins, A., van Daele, P.L.A., Leavis, H.L., Simons, A., Netea, Mihai G., Willems, H.P.J., Hoischen, A., de Sevaux, Ruud G.L., Potjewijd, Judith, van Daele, Paul L.A.; id_orcid, van der Veken, L.T., Hak, A.E., van der Veerdonk, Frank L   +51 more
core   +1 more source

Janus kinase inhibition for autoinflammation in DNASE2 deficiency [PDF]

, 2019
We characterise the immunopathogenesis of autoinflammation, HLH, and early onset intestinal inflammation caused by homozygous mutation in DNASE2, and provide the first description of favourable therapeutic response to JAK1/JAK2 blockade in this ...
Bader-Meunier, B, Booth, C, Sebire, N, Bullock, AN, Nanthapisal, S, Yasuda, T, Capitani, M, Pandey, S, Gilmour, K, Uhlig, HH, Cavounidis, A, Brogan, P, Hong, Y, Murphy, C, Omoyinmi, E, McCreary, D, Takeshita, H, Eleftheriou, D, Rao, A, Shah, N, Klein, N, Bullock, Alexander   +21 more
core   +1 more source