Results 211 to 220 of about 181,043 (245)
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Inherited Autoinflammatory Syndromes
Annual Review of Pathology: Mechanisms of Disease, 2022Autoinflammation describes a collection of diverse diseases caused by indiscriminate activation of the immune system in an antigen-independent manner. The rapid advancement of genetic diagnostics has allowed for the identification of a wide array of monogenic causes of autoinflammation.
Julia E, Rood, Edward M, Behrens
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Autoinflammatory Syndromes in Children
The Indian Journal of Pediatrics, 2016Systemic autoinflammatory diseases are rare disorders of innate immunity which usually present in childhood with recurrent or continuous attacks of fever and systemic inflammation. The discovery of the genetic defect underlying Familial Mediterranean fever in 1997 has proved exceptionally informative about the innate immune system and the regulation of
Ruth J, Pepper, Helen J, Lachmann
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Vasculitis in the autoinflammatory diseases
Current Opinion in Rheumatology, 2017Purpose of review This article addresses the prevalence and relationship between autoinflammatory diseases and vasculitis. Recent findings Autoimmune diseases (AIDs) are a group of syndromes characterized by episodes of unprovoked inflammation due to dysregulation of the innate ...
Hagit, Peleg, Eldad, Ben-Chetrit
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Autoinflammatory bone disorders
Current Opinion in Rheumatology, 2007This review provides an update on clinical, genetic, and immunologic aspects of the autoinflammatory bone disorders.Chronic noninfectious inflammation of the bone is a clinical feature of both chronic recurrent multifocal osteomyelitis and (to a lesser degree) cherubism.
Polly J, Ferguson, Hatem I, El-Shanti
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The Inflammasomes and Autoinflammatory Syndromes
Annual Review of Pathology: Mechanisms of Disease, 2015Inflammation, a vital response of the immune system to infection and damage to tissues, can be initiated by various germline-encoded innate immune-signaling receptors. Among these, the inflammasomes are critical for activation of the potent proinflammatory interleukin-1 cytokine family. Additionally, inflammasomes can trigger and maintain inflammatory
Lori Broderick +4 more
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Autoinflammatory Diseases (AID)
Klinische Pädiatrie, 2014Most of the autoinflammatory diseases (AID) are orphan diseases with recurrent episodes of systemic inflammation. Fever and exanthema are leading features. Given the ongoing elucidation of pathogenic causes and hence therapeutic approaches, we provided a review of the current literature of AID.
G, Dueckers, O, Sander, T, Niehues
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Psoriasis as Autoinflammatory Disease
Dermatologic Clinics, 2013This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined ...
Joaquin J, Rivas Bejarano +1 more
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Autoinflammatory diseases in children.
, 2010 Autoinflammatory diseases encompass a growing number of multisystem clinical entities with genetic or acquired defects in the innate immune system. Distinct conditions can be identified in this expanding sphere: familiar Mediterranean fever, mevalonate kinase deficiency, tumor necrosis factor receptor-associated periodic syndrome, cryopyrinopathies ...
Rigante, Donato
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Autoinflammatory associated vasculitis
Seminars in Arthritis and Rheumatism, 2016Autoinflammatory diseases are characterized by recurrent episodes of fever and localized or systemic inflammation and are caused by monogenic defects of innate immunity. The skin is commonly involved with various manifestations including erysipelas like rash and urticaria. Although vasculitis has been described in many autoinflammatory diseases, it has
Shira, Ginsberg +10 more
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Autoinflammatory bone disorders
Clinical Immunology, 2013Autoinflammatory bone disorders are characterized by chronic non-infectious osteomyelitis and inflammation-induced bone resorption and result from aberrant activation of the innate immune system. Sporadic chronic non-bacterial osteomyelitis (CNO) is the most common disease subtype.
Henner, Morbach +3 more
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