Results 231 to 240 of about 171,535 (264)
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Autoinflammatory Syndromes in Children
The Indian Journal of Pediatrics, 2016Systemic autoinflammatory diseases are rare disorders of innate immunity which usually present in childhood with recurrent or continuous attacks of fever and systemic inflammation. The discovery of the genetic defect underlying Familial Mediterranean fever in 1997 has proved exceptionally informative about the innate immune system and the regulation of
Ruth J, Pepper, Helen J, Lachmann
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Updates on autoinflammatory diseases
Current Opinion in Immunology, 2018Autoinflammatory diseases are hyperinflammatory, immune dysregulatory diseases caused by innate immune cells dysregulation that present typically in the perinatal period with systemic and organ-targeted inflammation, but with improved genetic testing and the development of diagnostic criteria, milder and later-onset forms are being detected in ...
Narcisa, Martinez-Quiles +1 more
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Autoinflammatory diseases in children.
, 2010 Autoinflammatory diseases encompass a growing number of multisystem clinical entities with genetic or acquired defects in the innate immune system. Distinct conditions can be identified in this expanding sphere: familiar Mediterranean fever, mevalonate kinase deficiency, tumor necrosis factor receptor-associated periodic syndrome, cryopyrinopathies ...
Rigante, Donato
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Autoinflammatory bone disorders
Current Opinion in Rheumatology, 2007This review provides an update on clinical, genetic, and immunologic aspects of the autoinflammatory bone disorders.Chronic noninfectious inflammation of the bone is a clinical feature of both chronic recurrent multifocal osteomyelitis and (to a lesser degree) cherubism.
Polly J, Ferguson, Hatem I, El-Shanti
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Amyloidosis in autoinflammatory syndromes
Autoimmunity Reviews, 2012AA amyloidosis may still dramatically impact on the outcome of patients with autoinflammatory diseases, particularly when diagnosis is delayed. Clinicians should maintain a high level of attention to identify early this severe complication. Initial signs mostly reflect kidney damage, with proteinuria, with or without renal failure, being the more ...
Obici, Laura, MERLINI, GIAMPAOLO
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Autoinflammatory syndromes for the dermatologist
Clinics in Dermatology, 2014While autoimmunity as cause of disease is well-established, other categories of immune-mediated diseases that are not produced by targeting of self-antigens by antibodies is in the process of being described. These so-called autoinflammatory diseases arise when an inappropriate activation of antigen-independent mechanisms occurs.
Paula, Dávila-Seijo +2 more
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The Inflammasomes and Autoinflammatory Syndromes
Annual Review of Pathology: Mechanisms of Disease, 2015Inflammation, a vital response of the immune system to infection and damage to tissues, can be initiated by various germline-encoded innate immune-signaling receptors. Among these, the inflammasomes are critical for activation of the potent proinflammatory interleukin-1 cytokine family. Additionally, inflammasomes can trigger and maintain inflammatory
Lori Broderick +4 more
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Autoinflammatory Diseases (AID)
Klinische Pädiatrie, 2014Most of the autoinflammatory diseases (AID) are orphan diseases with recurrent episodes of systemic inflammation. Fever and exanthema are leading features. Given the ongoing elucidation of pathogenic causes and hence therapeutic approaches, we provided a review of the current literature of AID.
G, Dueckers, O, Sander, T, Niehues
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Psoriasis as Autoinflammatory Disease
Dermatologic Clinics, 2013This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined ...
Joaquin J, Rivas Bejarano +1 more
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Autoinflammatory Diseases: A Review
The Journal of RheumatologyAutoinflammatory disease (AID) is a vast spectrum of disorders characterized by recurrent attacks of sterile inflammation. Since the first cloning of the familial Mediterranean fever gene in 1997, there has been a rapid rate of discovery of new AIDs.
Jason, An +2 more
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