Results 31 to 40 of about 178,684 (248)
Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
Frontiers in Immunology, 2022 Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an ubiquitously expressed protease presented as either a membrane-bound or soluble form.
Jie Huang +7 more
doaj +1 more source
Canakinumab for the treatment of autoinflammatory very early onset- inflammatory bowel disease
Frontiers in Immunology, 2022 IntroductionTherapeutic options are critically needed for children with refractory very early onset inflammatory bowel disease (VEO-IBD). Our aim was to evaluate clinical response to canakinumab, an anti-IL-1β monoclonal antibody, in patients with VEO ...
Eliana Shaul +13 more
doaj +1 more source
Systemic autoinflammatory disorders
Clinical and Experimental Pediatrics, 2023 Inflammation is a physiologic defense mechanism against an out-side attack. Usually, it resolves after the removal of noxious causes, but systemic autoinflammatory disorders (SAIDs) have recurrent or repeated acute inflammation through uncontrolled gene function, which can present as gain-of-function or loss-of-function of a gene during inflammation ...
openaire +3 more sources
Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra. [PDF]
, 2017 Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia.1 Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in
Barbareschi +9 more
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Swiss Medical Weekly, 2012 The monogenic autoinflammatory syndromes are conditions caused by mutations of genes coding for proteins that play a pivotal role in the regulation of the inflammatory response. Due to their genetic nature, most of these disorders have an early onset.
S Federici, R Caorsi, M Gattorno
openaire +4 more sources
Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]
, 2018 Funding/Support: No funding or grant support. Financial Disclosures: John V. Forrester has received an honorarium for lecturing from Janssen (London, UK). Lucia Kuffova has undertaken consultancy work for Abbvie (London, UK). Andrew D.
Dick, Andrew D. +2 more
core +4 more sources
HLA Class I or Class II and Disease Association: Catch the Difference if You Can [PDF]
, 2017 The association of autoimmune diseases with HLA has been known for many decades. To date, however, the underlying mechanisms have not been fully understood. The recently introduced genome-wide association studies (GWAS) have suggested that several genes
Fiorillo, Mt +3 more
core +7 more sources
Spectrum of Genetic Autoinflammatory Diseases Presenting with Cutaneous Symptoms
Acta Dermato-Venereologica, 2020 Autoinflammatory diseases comprise a group of chronic disabling entities characterized by inflammation without the presence of infectious agents, auto-antibodies or antigen-specific T-cells. Many autoinflammatory diseases are caused by monogenic defects,
Hanna Bonnekoh +5 more
doaj +1 more source
Reumatismo, 2023 Adenosine deaminase 2 deficiency (DADA2) is a rare monogenic vasculopathy caused by loss-of-function homozygous or compound heterozygous mutations in ADA2, formerly CECR1 (cat eye syndrome chromosome region 1) gene.
A. Colangelo +5 more
doaj +1 more source
Could pentraxin-3 be a new marker for subclinical inflammation in familial Mediterranean fever? [PDF]
, 2015 Not ...
Evrengül, Harun +3 more
core +1 more source