Results 71 to 80 of about 15,562 (187)
Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice
Advanced Science, EarlyView.CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu +8 more
wiley +1 more source
, 2018 [[abstract]]The objective was to investigate the upstream mechanisms of apoptosis which were triggered by a novel antimicrotubule drug, ABT-751, in a tumor protein p53 ( TP53)-deficient hepatocellular carcinoma-derived Hep-3B cells.
Wei, RJ;Wu, WR;Pan, CT;Yu, CY;Li, CF;Chen, LR;Liang, SS;Shiue, YL
core +1 more source
, 2017 Promoting cell death by autophagy could be a novel treatment for cancer. The major player in autophagy, p62, serves as a good therapeutic target. Ginkgetin, a biflavonoid from Ginkgo biloba leaves, exhibited promising anticancer activity in non-small ...
Bi, Wen Chuan +9 more
core +1 more source
Assessment of the effect of rTsCatL2 on Caco-2 autophagy.
, 2023 A: MDC fluorescence staining. The rTsCatL2-treated group showed bright green fluorescence and cells underwent autophagy; the EBSS-treated positive control group underwent autophagy, while no fluorescence was observed in MBP and PBS groups, scale bar: 100
Xiang Yu Meng (12935540) +8 more
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Cytoskeleton, EarlyView.ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith +9 more
wiley +1 more source
Mitofusin 2 Exerts a Protective Role in Ischemia Reperfusion Injury Through Increasing Autophagy
Cellular Physiology and Biochemistry, 2018 Background/Aims: Autophagy is essential for maintaining cellular homeostasis and the survival of terminally differentiated cells as neurons. In this study, we aim to investigate whether mitofusin 2, a mitochondrial fusion protein, mediates autophagy in ...
Cheng Peng +12 more
doaj +1 more source
iMetaMed, EarlyView.This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu +7 more
wiley +1 more source
Mycobacterial autolysosome biogenesis.
, 2013 (A, C) Localization of LAMP1 to p62-positive of ubiquitin-positive mycobacteria in DC2.4 cells. DC2.4 cells were infected with Alexa Fluor 405-labeled M. tuberculosis (blue) for 24 h and immunostained with anti-LAMP1 (red) and anti-p62 antibodies (green)
Toshinobu Horii (497195) +3 more
core +1 more source
Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis
iNew Medicine, EarlyView.This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang +3 more
wiley +1 more source
, 2021 a) Electron micrograph of the δ-cell in the monkey after the hydroxynonenal injections. δ-cell shows fusion of an autolysosome (Al) with a peroxisome (P) exhibiting membrane disruption. G: somatostatin granule without a halo, Ly: lysosome.
Piyakarn Boontem (11663090) +1 more
core +1 more source