Results 81 to 90 of about 15,562 (187)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Pediatric acute lung injury (ALI) is a life‐threatening syndrome defined by dysregulated pulmonary inflammation and impaired alveolar gas exchange, with limited therapeutic interventions. This study aims to evaluate the therapeutic efficacy and mechanistic basis of Olaparib, a clinically approved PARP inhibitor, using in vitro and in vivo ...
Fen Gong +5 more
wiley +1 more source
, 2017 본 발명은 IDF-11774 및 자가용해소체 형성 저해제를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명의 약학적 조성물은 암세포의 성장 및 생존을 억제하는 효능이 탁월하여 암을 효과적으로 예방 및 치료할 수 있다. 구체적으로 본 발명의 약학적 조성물은 IDF-11774 및 자가용해소체 형성 저해제를 병용함으로써, 암세포에서 자가용해소체(autolysosome)의 형성을 억제하여 암세포에 대한 아폽토시스 ...
반현승 +3 more
core
, 2017 In multicellular organisms, autophagy is induced as an innate defense mechanism. Notably, the obligate intracellular bacterium Ehrlichia chaffeensis resides in early endosome-like vacuoles and circumvents lysosomal fusion through ...
Taslima T. Lina +4 more
core +1 more source
Prevention of Early Onset of Breast Cancer With Ashwagandha
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm +2 more
wiley +1 more source
Low‐Dose Colchicine Ameliorates Doxorubicin Cardiotoxicity Via Promoting Autolysosome Degradation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground The only clinically approved drug that reduces doxorubicin cardiotoxicity is dexrazoxane, but its application is limited due to the risk of secondary malignancies.
Ying Peng +20 more
doaj +1 more source
The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease
Pediatric Investigation, EarlyView.Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia +3 more
wiley +1 more source
Aberrant autophagosome and autolysosome formation in spns1-mutant zebrafish.
, 2014 (A) Yolk opaqueness and LC3 puncta formation in spns1-mutant zebrafish embryos. For EGFP-LC3 transgenic spns1-mutant [Tg(CMV:EGFP-LC3);spns1hi891/hi891] fish siblings, bright-field and fluorescence images of wild-type (wt) control (upper) and spns1 ...
Shuji Kishi (53191) +12 more
core +1 more source
Phytotherapy Research, EarlyView.Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia +6 more
wiley +1 more source
Ultrastructure of lysosomal bodies in cells of mutant clone 6H.
, 2018 (a) A large autolysosome near defective mitochondria (arrowhead). (b and c) Clusters of lysosomal components in the cytoplasm of cells. (d and e) Vacuolated lysosomes with light contents and breaches in the membrane (arrowheads). (f) Light inclusions not
Ksenia N. Morozova (5866403) +6 more
core +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) lacks effective pharmacological therapies and is strongly associated with excessive fructose consumption. Ferroptosis and autophagy dysregulation are increasingly recognized as key drivers of MAFLD progression.
Puyu Zhang +11 more
wiley +1 more source