Results 61 to 70 of about 17,929 (235)

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. [PDF]

, 2014
Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise when dysregulated.
Batlevi, Yakup, Carromeu, Cassiano, Cortes, Constanza J, Frankowski, Harald, Garden, Gwenn A, Ivanov, Nishi, La Spada, Albert R, Le, Amy, Miranda, Helen C, Muotri, Alysson R, Sopher, Bryce L, Young, Jessica E   +11 more
core  

Ginsenoside Compound K Induces Ros-Mediated Apoptosis and Autophagic Inhibition in Human Neuroblastoma Cells In Vitro and In Vivo [PDF]

, 2019
Autophagy can result in cellular adaptation, as well as cell survival or cell death. Modulation of autophagy is increasingly regarded as a promising cancer therapeutic approach.
Chun, Sungkun, Kim, Eunhee, Oh, Jung-Mi
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence [PDF]

Journal of Biological Chemistry, 2020
Oxidative stress-induced DNA damage, the senescence-associated secretory phenotype (SASP), and impaired autophagy all are general features of senescent cells. However, the cross-talk among these events and processes is not fully understood. Here, using NIH3T3 cells exposed to hydrogen peroxide stress, we show that stress-induced DNA damage provokes the
Xiaojuan Han, Honghan Chen, Hui Gong, Xiaoqiang Tang, Ning Huang, Weitong Xu, Haoran Tai, Gongchang Zhang, Tingting Zhao, Chuhui Gong, Shuang Wang, Yu Yang, Hengyi Xiao   +12 more
openaire   +2 more sources

Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux

Journal of Advanced Research, 2022
Introduction: Vascular smooth muscle cell (VSMC) senescence in the vasculature results in vascular aging as well as age-related diseases, while metformin improves the inflamm-aging profile by enhancing autophagy.
Shi Tai, Jiaxing Sun, Yuying Zhou, Zhaowei Zhu, Yuhu He, Mingxian Chen, Hui Yang, Yichao Xiao, Tao Tu, Liang Tang, Xuping Li, Jianping Zeng, Xilong Zheng, Shenghua Zhou   +13 more
doaj   +1 more source

T-type Ca2+ Channels: T for Targetable [PDF]

, 2018
In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers have a negative impact on the ...
Cantí Nicolás, Carles, Crespí Sallán, Marta, Herreros Danés, Judit, Nàger Grifo, Mireia, Shaikh, Soni, Visa Pretel, Anna   +5 more
core   +2 more sources

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Maintenance and Decline of Neuronal Lysosomal Function in Aging

Cells
Lysosomes are central effectors of cellular maintenance, integrating the degradation of damaged organelles and protein aggregates with macromolecule recycling and metabolic signaling.
Ruiling Zhong, Claire E. Richardson
doaj   +1 more source

Caspase involvement in autophagy [PDF]

, 2017
Caspases are a family of cysteine proteases widely known as the principal mediators of the apoptotic cell death response, but considerably less so as the contributors to the regulation of pathways outside cellular demise.
A Gross, AB Parrish, AD Rubinstein, AL Anding, AM Abraha, B Zhivotovsky, BD Bell, BT Hyman, C Behrends, C Gaubitz, C He, CA Lamb, CA Mercer, CEL Chua, CH Jung, CH Jung, CL Birmingham, CM Kenific, D Denton, D Denton, D Denton, D Denton, D Narendra, D Oz-Arslan, DC Rubinsztein, DG McEwan, DH Cho, DJ Klionsky, DL Berry, DR McIlwain, E Kuranaga, E Wirawan, E Wong, G Bjørkøy, G Kroemer, G Marino, H Wu, HK Lee, HS Jeong, I Sirois, I Tanida, IG Ganley, Ioannis P Nezis, IP Nezis, IP Nezis, J Diao, J Geng, J Han, J Zhang, J Zirin, JA Pan, JA Seaman, JM Norman, JS Peterson, JS Peterson, K Takeshige, K Zhu, KG Lassen, KK Huynh, KR Parzych, KS Ferreira, L DeVorkin, L Galluzzi, L Lamy, LA Booth, LC Kim, LH Ho, M Djavaheri-Mergny, M Miura, M Tiwari, M Tiwari, M Ulgherait, M You, Ma Laussmann, MA Lynch-Day, ML Würstle, MM Young, N Mizushima, N Mizushima, N Mizushima, N Mizushima, NC Mulakkal, O Oral, P Nilsson, Panagiotis Tsapras, Q Sun, R Kang, R Mathew, R Nunez, R Zoncu, RSY Wong, S Alers, S Bortnik, S Huang, S Kaushik, S Pankiv, S Shalini, S Tu, SL Fink, T Hara, T Johansen, T Lamark, T Shpilka, V Deretic, V Pagliarini, VMS Betin, VMS Betin, W He, W Hou, WW Li, Y Ichimura, Y Zhao, Y Zhu, YB Zhang, YCC Hou   +114 more
core   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source