Results 41 to 50 of about 17,929 (235)
Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity [PDF]
Clinical Science, 2019 Abstract Doxorubicin (DOX) is widely used as a first-line chemotherapeutic drug for various malignancies. However, DOX causes severe cardiotoxicity, which limits its clinical uses. Oxidative stress is one of major contributors to DOX-induced cardiotoxicity.
Dong Zheng +10 more
openaire +2 more sources
The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach
Cells, 2018 Autophagy failure is implicated in age-related human disease. A decrease in the rate of protein degradation through the entire autophagy pathway, i.e., autophagic flux, has been associated with the onset of cellular proteotoxity and cell death.
André du Toit +4 more
doaj +1 more source
Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells
CellsIn eukaryotes, targeting intracellular components for lysosomal degradation by autophagy represents a catabolic process that evolutionarily regulates cellular homeostasis.
Po-Yuan Ke
doaj +1 more source
The downward spiral of tau and autolysosomes [PDF]
Autophagy, 2012 A growing body of research has connected autophagy to neurodegenerative diseases such as Alzheimer disease (AD). In autopsied AD brain, large multivesicular bodies accumulate in neurons. Knockout mice deficient for key autophagy genes demonstrate age-dependent neurodegeneration.
Ambegaokar, Suren S., Jackson, George R.
openaire +2 more sources
Antioxidants, 2022 Physalis peruviana-derived physapruin A (PHA) is a potent compound that selectively generates reactive oxygen species (ROS) and induces cancer cell death. Autophagy, a cellular self-clearance pathway, can be induced by ROS and plays a dual role in cancer
Tzu-Jung Yu +7 more
doaj +1 more source
p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines [PDF]
, 2014 BACKGROUND: Bone marrow stromal cell (BMSC) paracrine factor(s) can induce apoptosis in bone metastatic prostate cancer (PCa) cell lines. However, the PCa cells that escape BMSC-induced apoptosis can upregulate cytoprotective autophagy. METHODS: C4-2, C4-
Chang, Megan A. +5 more
core +1 more source
Autolysosomal β‐catenin degradation regulates Wnt‐autophagy‐p62 crosstalk
The EMBO Journal, 2013 The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-induced autophagy.
Petherick, Katy J +10 more
openaire +4 more sources
Quantifying autophagosomes and autolysosomes in cells using imaging flow cytometry [PDF]
Cytometry Part A, 2015 AbstractAutophagy dysregulation has been implicated in numerous diseases and many therapeutic agents are known to modulate this pathway. Therefore, the ability to accurately monitor autophagy is critical to understanding its role in the pathogenesis and treatment of many diseases.
Robin, Rajan +5 more
openaire +2 more sources
The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease
Frontiers in EndocrinologyNon-alcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome characterized by excessive fat deposition in hepatocytes and a major cause of end-stage liver disease.
Qiaohui Shen +9 more
doaj +1 more source
Mechanism of Acrosome Biogenesis in Mammals
Frontiers in Cell and Developmental Biology, 2019 During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome is essential to this fusion process (fertilization) in animals.
Muhammad Babar Khawar +4 more
doaj +1 more source