Results 21 to 30 of about 15,562 (187)

Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures

Cells, 2022
Dysfunctional autophagy is linked to neuronal damage in ischemia/reperfusion injury. The Ras-related protein 7 (Rab7), a member of the Rab family of small GTPases, appears crucial for the progression of the autophagic flux, and its activity is strictly ...
Francesca Luchetti, Maria G. Nasoni, Sabrina Burattini, Atefeh Mohammadi, Marica Pagliarini, Barbara Canonico, Patrizia Ambrogini, Walter Balduini, Russel J. Reiter, Silvia Carloni   +9 more
doaj   +1 more source

A conserved requirement for RME-8/DNAJC13 in neuronal autolysosome reformation in C. elegans and cultured mouse cortical neurons

, 2023
Autophagosomes fuse with lysosomes, forming autolysosomes that degrade engulfed cargo. To maintain lysosomal capacity, autolysosome reformation (ALR) must regenerate lysosomes from autolysosomes using a membrane tubule-based process.

core   +1 more source

Impact of the Autophagy Machinery on Hepatitis C Virus Infection

Viruses, 2011
Autophagy is a cellular process that catabolizes cytoplasmic components and maintains energy homeostasis. As a stress response, the autophagy machinery interconnects a wide range of cellular pathways, enhancing the spread of certain pathogens while ...
Marlène Dreux, Francis V. Chisari
doaj   +1 more source

RUNDC1 inhibits autolysosome formation and survival of zebrafish via clasping ATG14-STX17-SNAP29 complex

, 2023
Autophagy serves as a pro-survival mechanism for a cell or a whole organism to cope with nutrient stress. Our understanding of the molecular regulation of this fusion event remains incomplete.
He, Junling, Bai, Hua, Xiao, Shuai, Guo, Dong, Michalak, M., Chen, X., Tang, J., Zhou, C., Torraca, Vincenzo, Yang, Yuyan, Lyu, Hao, Xie, Yufei, Huang, Yuan, Liao, Zhiquan, Ali, Declan William, Zhang, Xin, Liu, Shicheng, Li, Shi, Ma, C., Liu, Nan, He, Chao, Yuan, Jinglei, Gou, Dongzhi, Wang, Shen, Yang, Jiaren, Dong, Xueying, Zhang, Rui, Hu, Mengyu   +27 more
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Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection

Viruses, 2020
Enterovirus A71 (EV-A71) is a major pathogen that causes severe and fatal cases of hand-foot-and-mouth disease (HFMD). HFMD caused by EV-A71 seriously endangers children’s health.
Weitao Su, Shan Huang, Huimin Zhu, Bao Zhang, Xianbo Wu   +4 more
doaj   +1 more source

RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux

Frontiers in Oncology, 2022
The natural product pectolinarigenin exerts anti-inflammatory activity and anti-tumor effects, and exhibits different biological functions, particularly in autophagy and cell cycle regulation.
Haiping Jiang, Haiping Jiang, Haiping Jiang, Dongzhi Zhang, Dongzhi Zhang, Dongzhi Zhang, Dongzhi Zhang, Karpov Denis Aleksandrovich, Karpov Denis Aleksandrovich, Karpov Denis Aleksandrovich, Karpov Denis Aleksandrovich, Junyi Ye, Junyi Ye, Junyi Ye, Lixiang Wang, Lixiang Wang, Lixiang Wang, Xiaofeng Chen, Xiaofeng Chen, Xiaofeng Chen, Ming Gao, Ming Gao, Ming Gao, Xinzhuang Wang, Xinzhuang Wang, Xinzhuang Wang, Tao Yan, Tao Yan, Tao Yan, He Yang, He Yang, He Yang, Enzhou Lu, Enzhou Lu, Enzhou Lu, Wenwu Liu, Wenwu Liu, Wenwu Liu, Cheng Zhang, Jianing Wu, Penglei Yao, Zhenying Sun, Xuan Rong, Sokhatskii Andrei Timofeevich, Sokhatskii Andrei Timofeevich, Sokhatskii Andrei Timofeevich, Sokhatskii Andrei Timofeevich, Safin Shamil Mahmutovich, Zhixing Zheng, Zhixing Zheng, Zhixing Zheng, Xin Chen, Xin Chen, Xin Chen, Shiguang Zhao, Shiguang Zhao, Shiguang Zhao, Shiguang Zhao   +57 more
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Mechanism of Acrosome Biogenesis in Mammals

Frontiers in Cell and Developmental Biology, 2019
During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome is essential to this fusion process (fertilization) in animals.
Muhammad Babar Khawar, Muhammad Babar Khawar, Hui Gao, Wei Li, Wei Li   +4 more
doaj   +1 more source

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Nature Communications, 2021
How phase separation participates in mitophagy remains unclear. Here the authors show that Nur77 and p62/SQSTM1 through “head-to-head” and “tail-to-tail” interactions form membraneless condensates capable of sequestering dysfunctional mitochondria and ...
Shuang-zhou Peng, Xiao-hui Chen, Si-jie Chen, Jie Zhang, Chuan-ying Wang, Wei-rong Liu, Duo Zhang, Ying Su, Xiao-kun Zhang   +8 more
doaj   +1 more source

Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells

Cells
In eukaryotes, targeting intracellular components for lysosomal degradation by autophagy represents a catabolic process that evolutionarily regulates cellular homeostasis.
Po-Yuan Ke
doaj   +1 more source

Rab7 knockout unveiled regulated autolysosome maturation induced by glutamine starvation

, 2018
Macroautophagy (simply called autophagy hereafter) is an intracellular degradation mechanism that is activated by nutrient starvation. Although it is well-known that starvation induces autophagosome formation in an mTORC1-dependent manner, whether ...
Yoshihiko Kuchitsu, Yuta Homma, Mitsunori Fukuda, Naonobu Fujita   +3 more
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