Results 21 to 30 of about 17,929 (235)
Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes… Wait, I’m confused [PDF]
Autophagy, 2014 When an autophagosome or an amphisome fuse with a lysosome, the resulting compartment is referred to as an autolysosome. Some people writing papers on the topic of autophagy use the terms "autolysosome" and "autophagolysosome" interchangeably. We contend that these words should be used to denote 2 different compartments, and that it is worthwhile ...
Daniel J, Klionsky +2 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a catabolic recycling process by which a cell degrades its own constituents to contribute to cell homeostasis or survival. We report that the small trafficking inhibitor Retro-2 impairs microtubule-dependent vacuolar trafficking in autophagy.
Valérie Nicolas, Vanessa Lievin-Le Moal
doaj +1 more source
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
core +2 more sources
Autophagy and urothelial carcinoma of the bladder: A review. [PDF]
, 2016 The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
Chandrasekar, Thenappan +1 more
core +2 more sources
Impact of the Autophagy Machinery on Hepatitis C Virus Infection
Viruses, 2011 Autophagy is a cellular process that catabolizes cytoplasmic components and maintains energy homeostasis. As a stress response, the autophagy machinery interconnects a wide range of cellular pathways, enhancing the spread of certain pathogens while ...
Marlène Dreux, Francis V. Chisari
doaj +1 more source
Viruses, 2022 In this study, we investigated the correlation between the mechanism involved in porcine epidemic diarrhea virus (PEDV) replication and autophagic flux. In this study, we found that as PEDV replicated, production of LC3-II was significantly induced up to
Jae-Yeon Park +3 more
doaj +1 more source
Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency [PDF]
, 2013 Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H[superscript +]-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that
Bayliss, Peter E. +12 more
core +6 more sources
Catch Me If You Can: The Link between Autophagy and Viruses [PDF]
, 2015 Cells employ active measures to restrict infection by pathogens, even prior to responses from the innate and humoral immune defenses. In this context selective autophagy is activated upon pathogen induced membrane rupture to sequester and deliver ...
Coyne, CB, Lennemann, NJ
core +8 more sources
Autophagy signaling in hypertrophied muscles of diabetic and control rats
FEBS Open Bio, 2023 Autophagy plays a vital role in cell homeostasis by eliminating nonfunctional components and promoting cell survival. Here, we examined the levels of autophagy signaling proteins after 7 days of overload hypertrophy in the extensor digitorum longus (EDL)
Maria V. M. Scervino +10 more
doaj +1 more source
Cp1/cathepsin L is required for autolysosomal clearance in Drosophila [PDF]
Autophagy, 2020 Macroautophagy/autophagy is a highly conserved lysosomal degradative pathway important for maintaining cellular homeostasis. Much of our current knowledge of autophagy is focused on the initiation steps in this process. Recently, an understanding of later steps, particularly lysosomal fusion leading to autolysosome formation and the subsequent role of ...
Tianqi Xu +8 more
openaire +3 more sources