Results 11 to 20 of about 17,929 (235)

Low‐Dose Colchicine Ameliorates Doxorubicin Cardiotoxicity Via Promoting Autolysosome Degradation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The only clinically approved drug that reduces doxorubicin cardiotoxicity is dexrazoxane, but its application is limited due to the risk of secondary malignancies.
Ying Peng, Zhonggen Li, Jianchao Zhang, Yunshu Dong, Chenglin Zhang, Yiming Dong, Yafei Zhai, Honglin Zheng, Mengduan Liu, Jing Zhao, Wenting Du, Yangyang Liu, Liping Sun, Xiaowei Li, Hailong Tao, Deyong Long, Xiaoyan Zhao, Xin Du, Changsheng Ma, Yaohe Wang, Jianzeng Dong   +20 more
doaj   +3 more sources

Clec16a is critical for autolysosome function and Purkinje cell survival [PDF]

Scientific Reports, 2016
CLEC16A is in a locus genetically linked to autoimmune diseases including multiple sclerosis, but the function of this gene in the nervous system is unknown.
Allen, Paul M., Beatty, Wandy L., Bosch, Marie K., DiAntonio, Aaron, Green, Karen, Hwang, Seungmin, Kambal, Amal, Kim, Jungsu, Kim, Sungsu, Kreamalmeyer, Darren, Lamb, Christopher A., Milam, Ashley, Orchard, Robert C., Ornitz, David M., Park, Sunmin, Pruett-Miller, Shondra M., Razi, Minoo, Redmann, Veronika, Schmidt, Robert E., Tooze, Sharon A., Virgin, Herbert W., Xiao, Maolei, Yokoyama, Christine C.   +22 more
core   +6 more sources

Sulforaphanes: disruptors of phagophores and autolysosomes

Autophagy Reports, 2022
Sulforaphane and its metabolites (SFNs) cause apoptosis in cancers and could be potential anti-cancer drugs. We focused on investigating the underlying mechanisms through which SFNs inhibit cancers. First, SFNs cause microtubule disruption by phosphorylated MAPK1/ERK2-MAPK3/ERK1-mediated activation of 26S proteasome leading to a microtubule-associated ...
Yan Zhou, Wei Wu
openaire   +3 more sources

MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans

Autophagy Reports, 2023
The caspase-like protease MALT1 promotes immune responses and oncogenesis in mammals by activating the transcription factor NF-κB. MALT1 is remarkably conserved from mammals to simple metazoans devoid of NF-κB homologs, like the nematode C. elegans.
Julie Vérièpe-Salerno, Silvia Podavini, Marcus J.C. Long, Irina Kolotuev, Muriel Cuendet, Margot Thome   +5 more
doaj   +1 more source

Scissors for autolysosome tubules [PDF]

The EMBO Journal, 2015
Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear.
Yang, Chen, Li, Yu
openaire   +2 more sources

Inhibition of autolysosomes by repurposing drugs as a promising therapeutic strategy for the treatment of cancers

All Life, 2022
Autophagy process coordinates lysosomal destruction of cytoplasmic materials including damaged organelles and proteins. The double-membranous ‘autophagosome’ selectively sequesters the cytosolic components, followed by ‘autolysosome’ formation for ...
Abdul Alim Al-Bari
doaj   +1 more source

Ataxia-Telangiectasia Mutated Is Involved in Autolysosome Formation

Biomolecules & Therapeutics, 2023
Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been evaluated as anticancer drugs to potentiate the cytotoxicity of DNA damage-based cancer therapy. ATM is also involved in autophagy,
Hwang, Mihwa, Jun, Dong Wha, Song, Bo Ram, Shim, Hanna, Lee, Chang-Hun, Kim, Sunshin   +5 more
openaire   +2 more sources

The Molecular Interplay between Human Coronaviruses and Autophagy

Cells, 2021
Coronavirus disease 2019 (COVID-19), caused by a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has instantaneously emerged as a worldwide pandemic.
Ankit Shroff, Taras Y. Nazarko
doaj   +1 more source

Autolysosomal exocytosis of lipids protect neurons from ferroptosis

Journal of Cell Biology, 2022
ABSTRACTDuring oxidative stress neurons release lipids that are internalized by glia. Defects in this coordinated process play an important role in several neurodegenerative diseases. Yet, the mechanisms of lipid release and its consequences on neuronal health are unclear.
Isha Ralhan, Jinlan Chang, Matthew J. Moulton, Lindsey D. Goodman, Nathanael Y.J. Lee, Greg Plummer, H. Amalia Pasolli, Doreen Matthies, Hugo J. Bellen, Maria S. Ioannou   +9 more
openaire   +2 more sources

Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures

Cells, 2022
Dysfunctional autophagy is linked to neuronal damage in ischemia/reperfusion injury. The Ras-related protein 7 (Rab7), a member of the Rab family of small GTPases, appears crucial for the progression of the autophagic flux, and its activity is strictly ...
Francesca Luchetti, Maria G. Nasoni, Sabrina Burattini, Atefeh Mohammadi, Marica Pagliarini, Barbara Canonico, Patrizia Ambrogini, Walter Balduini, Russel J. Reiter, Silvia Carloni   +9 more
doaj   +1 more source