Results 11 to 20 of about 15,562 (187)
Viruses, 2022 In this study, we investigated the correlation between the mechanism involved in porcine epidemic diarrhea virus (PEDV) replication and autophagic flux. In this study, we found that as PEDV replicated, production of LC3-II was significantly induced up to
Jae-Yeon Park +3 more
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Cell ReportsSummary: Autophagy is a highly conserved cellular process in which cytoplasmic contents are sequestrated by autophagosomes and delivered to lysosomes for degradation.
Wenyan Qu +6 more
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Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy [PDF]
BMC Biology, 2011 Background Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease.
Eils Roland +3 more
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Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins. [PDF]
FEBS Open BioEndogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Ikeda K.
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康复学报, 2016 Objective:To observe the effects of electroacupuncture (EA) at the Quchi (LI11) and Zusanli (ST36) acupoints on peri-infract striatal neural autophagy in middle cerebral artery occlusion (MCAO) -induced ischemia and reperfusion injured rats.Methods ...
Weilin LIU, Yunjiao LIN, Jing TAO
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The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation [PDF]
Nature CommunicationsAutophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules.
Agata N. Makar +10 more
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LAPTM5 Downregulation-Driven VAMP8 Phosphorylation Impairs Autophagosome-Lysosome Fusion and Aggravates Septic Acute Lung Injury. [PDF]
Adv Sci (Weinh)LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Jiang L +12 more
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Frontiers in Cell and Developmental Biology, 2020 Autophagy is a catabolic recycling process by which a cell degrades its own constituents to contribute to cell homeostasis or survival. We report that the small trafficking inhibitor Retro-2 impairs microtubule-dependent vacuolar trafficking in autophagy.
Valérie Nicolas, Vanessa Lievin-Le Moal
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The Molecular Interplay between Human Coronaviruses and Autophagy
Cells, 2021 Coronavirus disease 2019 (COVID-19), caused by a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has instantaneously emerged as a worldwide pandemic.
Ankit Shroff, Taras Y. Nazarko
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Autophagy signaling in hypertrophied muscles of diabetic and control rats
FEBS Open Bio, 2023 Autophagy plays a vital role in cell homeostasis by eliminating nonfunctional components and promoting cell survival. Here, we examined the levels of autophagy signaling proteins after 7 days of overload hypertrophy in the extensor digitorum longus (EDL)
Maria V. M. Scervino +10 more
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