2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation [PDF]
Viruses, 2017 Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo.
Yoke Fun Chan +2 more
exaly +6 more sources
Implications of autolysosome- astrocyte-associated signature in the pathogenesis of Alzheimer’s disease: evidence from artificial intelligence and multi-omics and clinical validation [PDF]
Frontiers in NeuroscienceBackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta plaques and neurofibrillary tangles. Dysfunctional cellular clearance mechanisms, particularly autophagy-lysosomal pathways, and reactive ...
Congmin Zhang, Dandan Song
doaj +2 more sources
VPS33A and VPS18 orchestrate porcine epidemic diarrhea virus replication by modulating autophagic flux [PDF]
VirulenceCompletion of autophagy through autophagosome-lysosome fusion represents a critical regulatory checkpoint that is frequently manipulated during viral infection, however, how coronaviruses exploit this terminal step remains incompletely understood ...
Liang Guo +7 more
doaj +2 more sources
The Role of Autophagy–Lysosomal Pathways in Photoreceptor Death in the rd10 Mouse Model of Inherited Retinal Degeneration [PDF]
CellsInherited retinal degenerations, such as retinitis pigmentosa, are a leading cause of irreversible vision loss, yet broadly effective treatments remain elusive.
Kirstan A. Vessey +7 more
doaj +2 more sources
WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
Nature Communications, 2019 After autophagic cargo degradation, autolysosomes undergo a reformation process to recycle lysosomal membrane components. Here, Dai et al. demonstrate that the actin nucleation promoting factor WHAMM is required for autolysosome reformation by providing ...
Hong-Wei Wang, Li Yu, Hong-Wei Wang
exaly +2 more sources
Optical Visualization of Red-GQDs’ Organelles Distribution and Localization in Living Cells
Frontiers in Pharmacology, 2022 Recently, there has been a rapidly expanding interest in a new nanomaterial, graphene quantum dots (GQDs), owing to its profound potential in various advanced applications.
Haifeng Hu +6 more
doaj +1 more source
Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy
JACC: Basic to Translational Science, 2023 Summary: Left ventricular reverse remodeling in heart failure is associated with improved clinical outcomes. However, the molecular features that drive this process are poorly defined.
Thomas G. Martin, PhD +6 more
doaj +1 more source
Antioxidants, 2022 An important virulence trait of Salmonella enterica serovar Typhimurium (S. Typhimurium) is the ability to avoid the host immune response, generating systemic and persistent infections.
Valentina P. Sebastián +13 more
doaj +1 more source
MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans
Autophagy Reports, 2023 The caspase-like protease MALT1 promotes immune responses and oncogenesis in mammals by activating the transcription factor NF-κB. MALT1 is remarkably conserved from mammals to simple metazoans devoid of NF-κB homologs, like the nematode C. elegans.
Julie Vérièpe-Salerno +5 more
doaj +1 more source
All Life, 2022 Autophagy process coordinates lysosomal destruction of cytoplasmic materials including damaged organelles and proteins. The double-membranous ‘autophagosome’ selectively sequesters the cytosolic components, followed by ‘autolysosome’ formation for ...
Abdul Alim Al-Bari
doaj +1 more source