The Role of Autophagy–Lysosomal Pathways in Photoreceptor Death in the rd10 Mouse Model of Inherited Retinal Degeneration [PDF]
CellsInherited retinal degenerations, such as retinitis pigmentosa, are a leading cause of irreversible vision loss, yet broadly effective treatments remain elusive.
Kirstan A. Vessey +7 more
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Viruses, 2017 Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo.
I-Ching Sam +2 more
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Autophagy and Mycobacterium Tuberculosis: the role of autophagy in antimicrobial immunity and therapy [PDF]
Frontiers in Cellular and Infection MicrobiologyTuberculosis (TB) remains one of the most severe infectious diseases worldwide, posing a persistent and increasingly serious threat to global public health.
Hong Lei +7 more
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WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
Nature Communications, 2019 After autophagic cargo degradation, autolysosomes undergo a reformation process to recycle lysosomal membrane components. Here, Dai et al. demonstrate that the actin nucleation promoting factor WHAMM is required for autolysosome reformation by providing ...
Anbang Dai, Li Yu, Hongwei Wang
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DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation [PDF]
Nature CommunicationsAutophagy classically functions to protect cells and organisms during stressful conditions by catabolizing intracellular components to maintain energy homeostasis.
Rui Zhang +23 more
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Peering into the ‘black box’ of pathogen recognition by cellular autophagy systems [PDF]
Microbial Cell, 2015 Autophagy is an intracellular process that plays an important role in protecting eukaryotic cells and maintaining intracellular homeostasis. Pathogens, including bacteria and viruses, that enter cells can signal induction of selective autophagy ...
Shu-chin Lai, Rodney J Devenish
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Ghrelin improves small intestinal barrier damage in sepsis by promoting miR-143/ATG2B-mediated autophagy. [PDF]
PLoS ONEIntestinal barrier damage is crucial for the development of sepsis. Ghrelin (GHS) can restore intestinal barrier function. However, the mechanisms of GHS on intestinal barrier damage in sepsis remain unclear.
Jingquan Liu +6 more
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Optical Visualization of Red-GQDs’ Organelles Distribution and Localization in Living Cells
Frontiers in Pharmacology, 2022 Recently, there has been a rapidly expanding interest in a new nanomaterial, graphene quantum dots (GQDs), owing to its profound potential in various advanced applications.
Haifeng Hu +6 more
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Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy
JACC: Basic to Translational Science, 2023 Summary: Left ventricular reverse remodeling in heart failure is associated with improved clinical outcomes. However, the molecular features that drive this process are poorly defined.
Thomas G. Martin, PhD +6 more
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Antioxidants, 2022 An important virulence trait of Salmonella enterica serovar Typhimurium (S. Typhimurium) is the ability to avoid the host immune response, generating systemic and persistent infections.
Valentina P. Sebastián +13 more
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