WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
Nature Communications, 2019 After autophagic cargo degradation, autolysosomes undergo a reformation process to recycle lysosomal membrane components. Here, Dai et al. demonstrate that the actin nucleation promoting factor WHAMM is required for autolysosome reformation by providing ...
Hongwei Wang, Li Yu, Anbang Dai
exaly +4 more sources
Kinesin 1 Drives Autolysosome Tubulation [PDF]
Developmental Cell, 2016 Autophagic lysosome reformation (ALR) plays an important role in maintaining lysosome homeostasis. During ALR, lysosomes are reformed by recycling lysosomal components from autolysosomes. The most noticeable step of ALR is autolysosome tubulation, but it is currently unknown how the process is regulated.
Qian Peter Su, Li Yu
exaly +3 more sources
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells [PDF]
Autophagy, 2019 Multiple sources contribute membrane and protein machineries to construct functional macroautophagic/autophagic structures. However, the underlying molecular mechanisms remain elusive. Here, we show that RAB2 connects the Golgi network to autophagy pathway by delivering membrane and by sequentially engaging distinct autophagy machineries. In unstressed
Mei Mei, Xinyi Wang, Xiao Jiang
exaly +3 more sources
Viruses, 2017 Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo.
Yoke Fun Chan +2 more
exaly +3 more sources
Ataxia-Telangiectasia Mutated Is Involved in Autolysosome Formation
Biomolecules and Therapeutics, 2023 Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been evaluated as anticancer drugs to potentiate the cytotoxicity of DNA damage-based cancer therapy. ATM is also involved in autophagy,
Chang-Hun Lee, Sunshin Kim
exaly +3 more sources
The Role of Autophagy–Lysosomal Pathways in Photoreceptor Death in the rd10 Mouse Model of Inherited Retinal Degeneration [PDF]
CellsInherited retinal degenerations, such as retinitis pigmentosa, are a leading cause of irreversible vision loss, yet broadly effective treatments remain elusive.
Kirstan A. Vessey +7 more
doaj +2 more sources
PI 3 P phosphatase activity is required for autophagosome maturation and autolysosome formation [PDF]
EMBO Reports, 2014 Autophagosome formation is promoted by the PI3 kinase complex and negatively regulated by myotubularin phosphatases, indicating that regulation of local phosphatidylinositol 3-phosphate (PtdIns3P) levels is important for this early phase of autophagy.
Hong Zhang +2 more
exaly +3 more sources
Autophagy and Mycobacterium Tuberculosis: the role of autophagy in antimicrobial immunity and therapy [PDF]
Frontiers in Cellular and Infection MicrobiologyTuberculosis (TB) remains one of the most severe infectious diseases worldwide, posing a persistent and increasingly serious threat to global public health.
Hong Lei +7 more
doaj +2 more sources
Migratory autolysosome disposal mitigates lysosome damage
Journal of Cell BiologyLysosomes, essential for intracellular degradation and recycling, employ damage-control strategies such as lysophagy and membrane repair mechanisms to maintain functionality and cellular homeostasis. Our study unveils migratory autolysosome disposal (MAD), a response to lysosomal damage where cells expel LAMP1-LC3 positive structures via autolysosome ...
Li Yu, Takami Sho, Ying Li
exaly +3 more sources
Optical Visualization of Red-GQDs’ Organelles Distribution and Localization in Living Cells
Frontiers in Pharmacology, 2022 Recently, there has been a rapidly expanding interest in a new nanomaterial, graphene quantum dots (GQDs), owing to its profound potential in various advanced applications.
Haifeng Hu +6 more
doaj +1 more source