Results 31 to 40 of about 15,562 (187)
Electron micrograph of the β-cell in the monkey after the hydroxynonenal injections.
, 2021 β-cell shows fusion of an autolysosome (Al) with a peroxisome (P) exhibiting membrane disruption (arrows). The autolysosome (Al) contains mitochondria-derived debris (asterisk). The neighbouring lysosome (Ly) shows membrane permeabilization.
Piyakarn Boontem (11663090) +1 more
core +1 more source
The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease
Frontiers in EndocrinologyNon-alcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome characterized by excessive fat deposition in hepatocytes and a major cause of end-stage liver disease.
Qiaohui Shen +9 more
doaj +1 more source
The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach
Cells, 2018 Autophagy failure is implicated in age-related human disease. A decrease in the rate of protein degradation through the entire autophagy pathway, i.e., autophagic flux, has been associated with the onset of cellular proteotoxity and cell death.
André du Toit +4 more
doaj +1 more source
Antioxidants, 2022 Physalis peruviana-derived physapruin A (PHA) is a potent compound that selectively generates reactive oxygen species (ROS) and induces cancer cell death. Autophagy, a cellular self-clearance pathway, can be induced by ROS and plays a dual role in cancer
Tzu-Jung Yu +7 more
doaj +1 more source
, 2023 Macroautophagy/autophagy is an essential pro-survival mechanism activated in response to nutrient deficiency. The proper fusion between autophagosomes and lysosomes is a critical step for autophagic degradation.
Zhou, C. +6 more
core +2 more sources
Frontiers in Aging Neuroscience, 2021 The pathogenesis of Alzheimer’s disease (AD) involves activation of many NLRP3 inflammatory bodies, which may be related to amyloid β peptide and aggregation of misfolded proteins. Autophagy is an important regulator of inflammatory bodies.
Wen Zhou +8 more
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Lysosome Targeting RedGreen-assay: Selective Autophagy Sensing Assay for Mammalian Cells
Bio-Protocol, 2019 The process of autophagy is an essential cellular mechanism, required to maintain general cell health through the removal of dysfunctional organelles, such as the ER, peroxisomes and mitochondria, as well as protein aggregates, and bacteria. Autophagy is
Victoria Riccio +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Maintenance and Decline of Neuronal Lysosomal Function in Aging
CellsLysosomes are central effectors of cellular maintenance, integrating the degradation of damaged organelles and protein aggregates with macromolecule recycling and metabolic signaling.
Ruiling Zhong, Claire E. Richardson
doaj +1 more source