Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection
Viruses, 2020 Enterovirus A71 (EV-A71) is a major pathogen that causes severe and fatal cases of hand-foot-and-mouth disease (HFMD). HFMD caused by EV-A71 seriously endangers children’s health.
Weitao Su +4 more
doaj +1 more source
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway [PDF]
, 2012 Background Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear.
Emilie Giaime +8 more
core +4 more sources
ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway
PLOS ONE, 2022 Mutations in ATP13A2 cause Kufor-Rakeb Syndrome (KRS), a juvenile form of Parkinson’s Disease (PD). The gene product belongs to a diverse family of ion pumps and mediates polyamine influx from lysosomal lumen. While the biochemical and structural studies highlight its unique mechanics, how PD pathology is linked to ATP13A2 function remains unclear ...
Yuta Hatori +4 more
openaire +4 more sources
Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis [PDF]
, 2013 INTRODUCTION: It is not well understood whether the process of autophagy is accelerated or blocked in sepsis, and whether it is beneficial or harmful to the immune defense mechanism over a time course during sepsis.
Eizo Watanabe +8 more
core +1 more source
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]
, 2016 Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping +7 more
core +2 more sources
Frontiers in Oncology, 2022 The natural product pectolinarigenin exerts anti-inflammatory activity and anti-tumor effects, and exhibits different biological functions, particularly in autophagy and cell cycle regulation.
Haiping Jiang +57 more
doaj +1 more source
Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley [PDF]
, 2018 Microspores are reprogrammed towards embryogenesis by stress. Many microspores die after this stress, limiting the efficiency of microspore embryogenesis. Autophagy is a degradation pathway that plays critical roles in stress response and cell death.
Berenguer, Eduardo +4 more
core +1 more source
Autophagy in Microglia and Alzheimer's disease [PDF]
, 2019 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
core +1 more source
Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes [PDF]
Biology Open, 2015 ABSTRACTAutophagy is an intracellular recycling and degradation process, which is important for energy metabolism, lipid metabolism, physiological stress response and organism development. During Drosophila development, autophagy is up-regulated in fat body and midgut cells, to control metabolic function and to enable tissue remodelling.
Bader, C. +4 more
openaire +5 more sources
Nature Communications, 2021 How phase separation participates in mitophagy remains unclear. Here the authors show that Nur77 and p62/SQSTM1 through “head-to-head” and “tail-to-tail” interactions form membraneless condensates capable of sequestering dysfunctional mitochondria and ...
Shuang-zhou Peng +8 more
doaj +1 more source