Results 151 to 160 of about 1,031,034 (270)

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): acute pain and recovery during the first 7 days

open access: yesAnaesthesia, EarlyView.
Summary Introduction The majority of surgical cases in the UK occur in a day‐case setting. Published short‐term follow‐up studies after day‐case surgery are lacking and patterns of recovery including pain and patient reported outcome measures, are largely unknown. Methods Data from the Patient‐reported Outcomes, Postoperative Pain and pain relief after
Matthew Everson   +2177 more
wiley   +1 more source

Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. [PDF]

open access: yesEur Heart J
O'Neill MJ   +12 more
europepmc   +1 more source

Optimizing for Information Content on Ionflux Mercury Automated Patch Clamp [PDF]

open access: yesBiophysical Journal, 2020
Arpad Mike   +5 more
openaire   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade   +7 more
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

open access: yesBritish Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Automated patch-clamp recordings for detecting activators and inhibitors of the epithelial sodium channel (ENaC). [PDF]

open access: yesPflugers Arch
Sure F   +7 more
europepmc   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy