Results 161 to 170 of about 1,031,034 (270)

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Progressively Projected Newton's Method

Computer Graphics Forum, EarlyView.
Abstract Newton's Method is widely used to find the solution of complex non‐linear simulation problems. To guarantee a descent direction, it is common practice to clamp the negative eigenvalues of each element Hessian prior to assembly—a strategy known as Projected Newton (PN)—but this perturbation often hinders convergence.
J. A. Fernández‐Fernández, F. Löschner, J. Bender   +2 more
wiley   +1 more source

The Plant Alkaloid Harmaline Blocks the Voltage-Gated Sodium Channel Na_v1.7: A Study Using an Automated Patch-Clamp. [PDF]

Int J Mol Sci
Eisfeld J, Schumacher M, Krautwald M, Wierschke S, Qin L, Fechtali T, Brinkmeier H.   +6 more
europepmc   +1 more source

Modelización y simulación de corrientes iónicas de potasio en células cardiacas a partir de datos de patch-clamp. Desarrollo de la herramienta Voltage Clamp Fit

, 2012
VCF. HERRAMIENTA INFORMATICA QUE A PARTIR DE DATOS DE PATCH CLAMP, AUTOMATIZA LA ESTIMACION DE LOS PARAMETROS CINETICOS DE LOS PPALES CANALES DE POTASIO.Cruz Montilla, N. (2012).
Cruz Montilla, Natalia
core  

Authoring Terrestrial Planets with Diffusion Models

Computer Graphics Forum, EarlyView.
Abstract To support the design and subsequent generation of terrestrial planets for use in the creative media, we propose a solution that employs a generative model trained on satellite data from planetary bodies with a defined solid surface, such as the Earth and Mars.
Oliver Borg, James Gain, Éric Guérin, Adrien Peytavie, Marie‐Paule Cani, Eric Galin, Guillaume Cordonnier   +6 more
wiley   +1 more source

Mixed Super‐Circles

Computer Graphics Forum, EarlyView.
Abstract We introduce mixed super‐circles, a position‐curvature formulation of the original dynamic 2D super‐helix model. Compared to the latter, purely curvature‐based model – the so‐called chained formulation –, the mixed formulation that we propose here drastically reduces the algorithmic complexity of the solving scheme – from quadratic to quasi ...
Emile Hohnadel, Thibaut Métivet, Florence Bertails‐Descoubes   +2 more
wiley   +1 more source

Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying K_ir2.1 Channels on an Automated Patch-Clamp Platform. [PDF]

Assay Drug Dev Technol, 2019
Sanson C, Schombert B, Filoche-Rommé B, Partiseti M, Bohme GA.   +4 more
europepmc   +1 more source

Differentiable Variable Fonts

Computer Graphics Forum, EarlyView.
Abstract Typography is an essential component of visual communication. Editing and animating text appearance for graphic designs, title sequences, commercials, and logos remain highly skilled tasks requiring detailed, hands‐on efforts from pro artists. Automating these challenging manual workflows requires balancing the competing goals of maintaining a
Kinjal Parikh, Danny M. Kaufman, David I.W. Levin, Alec Jacobson   +3 more
wiley   +1 more source

CANRIG: Cross‐Attention Neural Face Rigging with Variable Local Control

Computer Graphics Forum, EarlyView.
Abstract Facial animation is one of the most labor‐intensive aspects of animation and VFX, as traditional rigging consumes weeks of expert time and forces animators to spend countless hours manipulating hundreds of controls to achieve varied expressions.
Arad Mohammadi, Sebastian Weiss, Jakob Buhmann, Loic Ciccone, Robert W. Sumner, Derek Bradley, Martin Guay   +6 more
wiley   +1 more source