Results 181 to 190 of about 1,031,034 (270)

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

The Journal of Physiology, EarlyView.
Abstract figure legend We used an optogenetic gain‐of‐function manipulation to investigate how sensory signals from two subtypes of Aβ low threshold mechanoreceptors (LTMRs) contribute to the cortical representation of touch. CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed‐light generation of high‐frequency action potential trains ...
Wanyi Liu, Andrew E. Worthy, Alan J. Emanuel   +2 more
wiley   +1 more source

Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay. [PDF]

Acta Pharmacol Sin, 2016
Yu HB, Zou BY, Wang XL, Li M.
europepmc   +1 more source

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

hERG1 channels and potential therapeutics for long QT syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider, Kelly A. Aromolaran, Michael C. Sanguinetti, Ademuyiwa S. Aromolaran   +3 more
wiley   +1 more source

Late cardiac sodium current can be assessed using automated patch-clamp. [PDF]

F1000Res, 2014
Chevalier M, Amuzescu B, Gawali V, Todt H, Knott T, Scheel O, Abriel H.   +6 more
europepmc   +1 more source

KV channels contribute to thermal hyperaemia in skeletal muscle of humans

The Journal of Physiology, EarlyView.
Abstract figure legend Using skeletal muscle microdialysis and pulsed short‐wave diathermy, we examined the contribution of KV channels to thermal hyperaemia in human skeletal muscle. KV channel antagonism with 4‐aminopyridine attenuated thermal hyperaemia by ∼65%, identifying a critical downstream role for these ion channels in the vasodilatory ...
Ysabella I. Ruiz‐Pick, Sophia G. Wagle‐Babb, Asim Kichloo, Albert H. Olivencia‐Yurvati, Gregory M. Dick, Steven A. Romero   +5 more
wiley   +1 more source

Correction to: Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology. [PDF]

Biol Methods Protoc
europepmc   +1 more source

Scaling‐Up Vanadium Redox Flow Batteries: From Lab‐Scale Flow Cells to Application Stacks

Advanced Chemical Engineering, Volume 1, Issue 2, December 2026.
The transition of vanadium redox flow batteries (VRFBs) from laboratory cells to practical stacks encounters integrated limitations in key components. This review emphasizes component‐level optimization and engineering considerations for electrodes, electrolytes, membranes, and flow fields. Critical trade‐offs among different metrics across large‐scale
Xin Long, Xiaoyu Huo, Yuran Bai, Enkang Fu, Xusong Gong, Zhongchao Tan, Liang An   +6 more
wiley   +1 more source

A highly accurate, low‐cost method for detecting and quantifying soybean leaf flipping phenotype during drought stress

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract A genome‐wide association study (GWAS) using digital images was conducted to delineate regions of the genome that govern the leaf flipping quantitative trait in soybean (Glycine max (L.) Merr). However, converting the digital data to numerical scores for downstream analyses was challenging.
Mohammad Anisur Rahaman, Atit Parajuli, Adnan Hossain Khan, Liang Dong, Madan K Bhattacharyya   +4 more
wiley   +1 more source