Results 121 to 130 of about 1,044,066 (265)

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology. [PDF]

Biol Methods Protoc, 2021
Ng CA, Farr J, Young P, Windley MJ, Perry MD, Hill AP, Vandenberg JI.   +6 more
europepmc   +1 more source

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

Dynamic Reconstruction of Atomically Dispersed Copper Catalysts for CO2 Reduction: From In Situ Observations to Rational Design

EcoEnergy, EarlyView.
Dynamic reconstruction transforms atomically dispersed Cu catalysts into authentic working‐state active phases during CO2 electroreduction. By integrating operando characterization, multiscale simulations, and AI‐assisted predictive modeling, this review establishes a framework for understanding, predicting, and rationally engineering catalyst ...
Jin Liu, Yue‐Wen Fang
wiley   +1 more source

A multiple recording patch clamp chip with integrated subterranean microfluidic channels for cultured neuronal networks

, 2008
We report on a new type of patch-clamp chip that can simultaneously monitor electrophysiological activity from several individual neurons grown in simple networks.
Py, Christophe, Martinez, Dolores, Ahuja, Tarun, Denhoff, Mike, Monette, Robert, Mealing, Geoff, Charrier, Anne, Krantis, Anthony, Comas, Tanya, Wingar, Simon   +9 more
core   +1 more source

Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology. [PDF]

Front Pharmacol, 2021
Pesti K, Földi MC, Zboray K, Toth AV, Lukacs P, Mike A.   +5 more
europepmc   +1 more source

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source

A Comprehensive Review of Fault‐Current Limiter Technologies for Smart and Resilient Power Systems

Energy Science &Engineering, EarlyView.
This review compares superconducting, solid‐state, and hybrid fault‐current limiters (FCLs) for modern alternating current, direct current, and hybrid grids. It shows that optimal FCL selection depends on fault characteristics, network configuration, voltage level, protection coordination, and resilience requirements rather than on a universally ...
Abdelrahman Farghly, Eslam Essam, Hilmy Awad, Samia Abdelfatah, Walid Issa, Abdallah M. Hamada   +5 more
wiley   +1 more source

Pancreatic α‐cell dysfunction associated with equine insulin dysregulation

Equine Veterinary Journal, EarlyView.
Abstract Background Insulin dysregulation (ID) in horses is characterised by insulin resistance and exaggerated insulin responses, yet the underlying endocrine mechanisms remain incompletely understood. In humans, α‐cell dysfunction characterised by exaggerated glucagon secretion contributes to metabolic disease; however, the role of pancreatic α‐cell ...
Sanna Lindåse, Emma Strage, Josefin Söder, Johan Bröjer   +3 more
wiley   +1 more source

Genotype‐function‐phenotype correlations for SCN1A variants identified by clinical genetic testing

Annals of Clinical and Translational Neurology
Objective Interpretation of clinical genetic testing, which identifies a potential genetic etiology in 25% of children with epilepsy, is limited by variants of uncertain significance. Understanding functional consequences of variants can help distinguish
Andrew T. Knox, Christopher H. Thompson, Dillon Scott, Tatiana V. Abramova, Bethany Stieve, Abigail Freeman, Alfred L. George Jr.   +6 more
doaj   +1 more source

Experimental Characterization of the Effects of Mineral‐Based Fire‐Retardant Admixtures on the Combustion Properties of Polyethylene Blends

Fire and Materials, EarlyView.
ABSTRACT The growing demand for flame retardant (FR) polymeric materials has highlighted the need to improve the combustion behaviour of highly flammable polymers such as polyethylene (PE). This study investigates the use of eco‐sustainable mineral FRs as a strategy to reduce heat release and smoke production during combustion, while improving the ...
Linda Vitaloni, Diego Tirelli, Lucia Campanelli, Bruno Dal Lago   +3 more
wiley   +1 more source