Results 171 to 180 of about 1,044,066 (265)
The FEBS Journal, EarlyView.Using solid‐supported membrane electrophysiology, we resolved three electrogenic events during GABA transport by the human GAT‐1 transporter. A rapid occlusion step (E1) is followed by a GABA‐induced Na+ leak current (E2), which becomes prominent under steep Na+ gradients, and a slower current associated with Na+‐coupled GABA transport (E3 ...
Rocco Zerlotti +8 more
wiley +1 more source
Axial and Biaxial Fatigue Behavior of 6061‐T651 Cold Metal Transfer Welded Joints
Fatigue &Fracture of Engineering Materials &Structures, EarlyView.ABSTRACT Lightweight aluminum structures in transportation systems are increasingly exposed to complex service loading, yet the fatigue performance of welded joints is still predominantly assessed using uniaxial data. In this work, the axial and biaxial fatigue behavior of 6061‐T651 aluminum alloy joints produced by cold metal transfer (CMT) welding is
R. Serrano, R. R. Ambriz, G. Ayoub
wiley +1 more source
Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells. [PDF]
J Pharmacol Toxicol Methods, 2016 Yuan NY +5 more
europepmc +1 more source
Journal of Prosthodontics, EarlyView.Abstract Purpose Passive fit in implant‐supported complete‐arch prostheses is the key to long‐term success. The aim of this in vitro, proof‐of‐concept study was to examine whether torque/time graphs generated from a surgical motor during the prosthetic screw insertion process show consistent patterns of digitally controlled angular and linear misfits ...
Carla Vidal‐Ponsoda +5 more
wiley +1 more source
New Phytologist, EarlyView.Climate‐of‐origin of Themeda triandra populations used in this study. Summary Hydraulic, stomatal, and anatomical traits strongly influence plant performance under drought, but the extent to which these trait‐types are coordinated and relate to climate‐of‐origin remains vastly underexplored in herbaceous species relative to woody plants.
Vinod Jacob +8 more
wiley +1 more source
TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice
The Journal of Physiology, EarlyView.Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
wiley +1 more source
Amyloid β alters vascular CaV1.2 channel spatiotemporal properties
The Journal of Physiology, EarlyView.Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor +5 more
wiley +1 more source
Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay. [PDF]
Acta Pharmacol Sin, 2016 Yu HB, Zou BY, Wang XL, Li M.
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa +6 more
wiley +1 more source
Late cardiac sodium current can be assessed using automated patch-clamp. [PDF]
F1000Res, 2014 Chevalier M +6 more
europepmc +1 more source