Results 191 to 200 of about 1,044,066 (265)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, Volume 183, Issue 23, Page 6824-6846, December 2026.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition. [PDF]

Elife
Fujita A, Jo S, Stewart RG, Osorno T, Ferraiuolo A, Carlin K, Bean BP.   +6 more
europepmc   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, Volume 183, Issue 23, Page 6787-6800, December 2026.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Multimodal single-cell dataset of juvenile rat neocortical interneurons-Morphology, whole-cell patch electrophysiology and histological slices. [PDF]

Front Neurosci
Toledo-Rodriguez M, Shi Y, Meystre J, La Mendola D, Ranjan R, Soltuzu L, Pezzoli M, Perin RC, Markram H.   +8 more
europepmc   +1 more source

Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques. [PDF]

Acta Pharmacol Sin, 2016
Yue JF, Qiao GH, Liu N, Nan FJ, Gao ZB.
europepmc   +1 more source

Sensor‐Detected Hypoglycaemia Is Associated With Inflammatory Protein and Immune Cell Alterations in People With Diabetes: Findings From the Hypo‐METRICS Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11496-11507, December 2026.
ABSTRACT Aims Experimental hypoglycaemia induces a persistent inflammatory response. We investigated whether real‐life sensor‐detected hypoglycaemia (SDH) is associated with immune parameters in people with Type 1 and Type 2 diabetes and explored potential differences between the groups.
Mandala Ajie, Namam Ali, Marijn S. Hendriksz, Patrick Divilly, Marloes J. Rietveld, Evertine J. Abbink, Pratik Choudhary, Julie Maria Bøggild Brøsen, Ulrik Pedersen‐Bjergaard, Rory J. McCrimmon, Mark Evans, Julia K. Mader, Bastiaan E. de Galan, Rinke Stienstra, Cees J. Tack, on behalf of the Hypo‐RESOLVE Consortium   +15 more
wiley   +1 more source

Simulation‐Based Analysis of Insert Pull‐Out in Nickel‐Polyurethane Hybrid Foams Using CT‐Derived Geometries

Advanced Engineering Materials, Volume 28, Issue 21, 4 November 2026.
CT‐based finite element simulations combined with in situ X‐ray computed tomography are used to analyze insert pull‐out in nickel‐coated polymer foams. Despite variations in material parameters, deformation consistently concentrates within a narrow annular region around the insert.
Yannik Bautz, Jonas Fell, Hendrik Jost, Stefan Diebels, Hans‐Georg Herrmann   +4 more
wiley   +1 more source

Micropillar‐Engineered Hybrid Adhesive Patch for Surface‐Conformable and Directional Adhesion

Advanced Materials Technologies, Volume 11, Issue 21, 6 November 2026.
This work presents a surface‐conformable hybrid adhesive integrating height‐optimized hexagonal micropillars with open‐rectangular cuts. The micropillars enhance rough‐surface contact and microscale crack arrest, while the cuts guide and reverse interfacial cracks for strong and directional adhesion. The multiscale architecture achieves robust pull‐off
Seongjin Park, Dong Kwan Kang, Haejin Bae, Ho‐Sup Jung, Hoon Eui Jeong   +4 more
wiley   +1 more source

Multimodal <i>KCNQ1</i> Variant-Effect Maps Define Ion Channel Mechanisms and Disease Risk. [PDF]

Circulation
Harvey ML, Osborn E, Lancaster MC, Smith JE, Shen Q, Abe TA, Cai R, Muhammad A, Kannankeril R, Yang T, Calandranis ME, Blackwell DJ, Dolder RE, Aldridge JL, Fleming MR, Blair MA, Soria E, O'Sullivan JW, Davogustto G, Kroncke BM, MacRae CA, Knollmann BC, Roth FP, Parikh VN, Ashley EA, Vandenberg JI, Ng CA, Roden DM, Glazer AM.   +28 more
europepmc   +1 more source

Chronic Electroconvulsive Shock Disrupts Hippocampal Physiology and Impairs Associative Memory in Mice

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Electroconvulsive therapy (ECT) is a highly effective treatment for depression but it has undesirable side effects on various aspects of cognition, including memory. Patients may display retrograde amnesia for autobiographical events and anterograde amnesia in tests of recall and recognition memory. These amnestic effects are likely to depend,
T. R. Zhang, N. P. Vyleta, I. Schwein, B. Askari, M. B. Cooke, F. Vila‐Rodriguez, J. S. Snyder   +6 more
wiley   +1 more source