Results 211 to 220 of about 1,044,066 (265)

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex. [PDF]

Pflugers Arch
Peng Y, Mittermaier FX.
europepmc   +1 more source

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species. [PDF]

Exp Physiol
Ranjan R, Logette E, Herzog M, Buchillier V, Scantamburlo E, Markram H.   +5 more
europepmc   +1 more source

Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review. [PDF]

J Cannabis Res
Castro SG, Silva SE, Brito JCM, Matavel A.   +3 more
europepmc   +1 more source

NS1643 enhances the activity of T1019PfsX38 and Q1070X hERG channels associated with long QT syndrome type 2. [PDF]

Pflugers Arch
Al Salmani MK, Al Kharusi A, Al Rawahi M, Albarwani S.   +3 more
europepmc   +1 more source

Optimization of Pyrazole-Based Activators of Kv3.1. [PDF]

ACS Med Chem Lett
Spearing PK, Satpute Janve V, Romaine IM, Jayakodiarachchi N, Guttentag BW, Jana S, Kim K, Denton JS, Lindsley CW, Waterson AG.   +9 more
europepmc   +1 more source

Analysis of sodium self-inhibition of the epithelial sodium channel (ENaC) using classical and medium-throughput automated two-electrode voltage-clamp recordings. [PDF]

Pflugers Arch
Luján López KL, Furtwängler N, Frank CM, Althaus M, Rauh O.   +4 more
europepmc   +1 more source

Optimization of automated patch-clamp technique and comparative analysis with manual patch-clamp: A case study on the TRPV1 channel

Journal of Chinese Pharmaceutical Sciences
openaire   +1 more source