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Automated Radiosynthesis of [11C]Morphine for Clinical Investigation [PDF]

Applied Radiation and Isotopes, 2011
To meet a multiple-dose clinical evaluation of the P-gp modulation of [(11)C]morphine delivery into the human brain, radiosynthesis of [(11)C]morphine was accomplished on an automated system by N-methylation of normorphine with [(11)C]CH(3)I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed.
Konrad Meissner, Evan D Kharasch, Robert H Mach   +2 more
exaly   +3 more sources

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An Automated Radiosynthesis of (S)-[18F]28 for PET Imaging of Alzheimer's Disease

Applied Radiation and Isotopes, 2021
18F-labeled 2-arylbenzoxazole derivative (S)-[18F]28 is potent and selective radiopharmaceutical Aβ tracers for Alzheimer's disease positron-emission tomography (PET). Our study aimed to enable facile preparation of (S)-[18F]28 in commercially available PET tracer production facilities to promote the widespread application and clinical translation ...
Qiang Xie, Ji-Kui Xie
exaly   +3 more sources

Automated radiosynthesis of [18F]ciprofloxacin

Applied Radiation and Isotopes, 2015
We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass ...
Johann, Stanek, Severin, Mairinger, Thomas, Wanek, Claudia, Kuntner, Markus, Müller, Oliver, Langer   +5 more
openaire   +2 more sources

The automated radiosynthesis of [18F]FP-TZTP

Nuclear Medicine and Biology, 2003
[(18)F]FP-TZTP (3-(3-(3-[(18)F]fluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine) is a muscarinic ligand that displays in vivo selectivity for the M2 subtype. We have developed a one-step radiosynthesis of [(18)F]FP-TZTP that can be conducted with an automated synthesis unit. A number of hardware and software modifications to
Dale O, Kiesewetter, Bik-kee, Vuong, Michael A, Channing   +2 more
openaire   +2 more sources

Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer

Nuclear Medicine Communications, 2008
The Pittsburgh compound-B ([11C]PIB) is a highly interesting radiotracer for imaging amyloid plaques in Alzheimer's disease by positron emission tomography (PET). An increasing number of PET centres schedule its transfer for clinical studies and therefore are interested in its automated synthesis.With the aim of flexibility, we reported the first fully
Mathieu, Verdurand, Guillaume, Bort, Vincent, Tadino, Fréderic, Bonnefoi, Didier, Le Bars, Luc, Zimmer   +5 more
openaire   +2 more sources

Improved and semi-automated GMP-compliant radiosynthesis of [11C]docetaxel

Applied Radiation and Isotopes, 2008
[(11)C]Docetaxel (Taxotere) has been synthesized via an improved synthesis route, which involves a more efficient intermediate removal of the excess 1,2,2,2-tetrachloroethyl chloroformate. Furthermore, the purification and formulation into a human applicable solution of [(11)C]docetaxel was developed.
van Tilburg, E.W., Mooijer, M.P., Brinkhorst, J., van der, M.M., Windhorst, A.D.   +4 more
openaire   +4 more sources

Automated radiosynthesis and purification of [ 18 F]flumazenil with solid phase extraction

Applied Radiation and Isotopes, 2018
This paper describes the novel approach for preparation of [18F]flumazenil ([18F]FMZ), well known radioligand for assessment of GABAA receptors by PET. The optimized reaction conditions allowed us to implement commercially available SPE cartridges for [18F]FMZ purification avoiding HPLC. All procedures were performed with TRACERlab FX N Pro synthesizer
Daria, Vaulina, Morteza, Nasirzadeh, Natalia, Gomzina   +2 more
openaire   +2 more sources

Automated and efficient radiosynthesis of [18F]FLT using a low amount of precursor

Nuclear Medicine and Biology, 2016
Since 1991 until now, many radiosyntheses of [(18)F]FLT have been published. Most of them suffer from side reactions and/or difficult purification related to the large amount of precursor necessary for the labeling step. A fully automated synthesis using only commercial and unmodified materials with a reduced amount of precursor would be desirable.We ...
Marchand, Patrice, Ouadi, Ali, Pellicioli, Michel, Schuler, Jacky, Laquerriere, Patrice, Boisson, Frédéric, Brasse, David   +6 more
openaire   +4 more sources

Automated, Transferable, and Ethanol-Free Radiosynthesis of [¹¹C]Butanol

ACS Chemical Neuroscience
Cerebral blood flow and blood-brain barrier permeability assessment are crucial hemodynamic parameters to measure under neurological conditions. In conjunction with positron emission tomography (PET), oxygen-15-labeled water has emerged as a gold standard for measuring cerebral perfusion; however, at higher flow rates, [15O]water extraction becomes ...
Olujide Oyeniran, Linshan Liu, Confidence Raymond, Paulien Moyaert, Michael S. Kovacs, Udunna C. Anazodo, Justin W. Hicks   +6 more
openaire   +2 more sources

Automated radiosynthesis of GMP quality [ 18 F]HX4 for PET imaging of hypoxia

Nuclear Medicine and Biology, 2015
[(18)F]HX4 is a 2-nitroimidazole based investigational radiotracer for imaging hypoxia.A two-step, one-pot synthetic procedure was developed on a GE Tracerlab MX-FDG with a disposable cassette. Nucleophilic substitution of a nosylate group with [(18)F]fluoride was followed by solvent evaporation and acidic removal of the acetyl protecting group.
David R, Turton, Helen M, Betts, David, Dutton, Alan C, Perkins   +3 more
openaire   +2 more sources