Results 61 to 70 of about 6,125,993 (245)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Remote supervision of an autonomous surface vehicle using virtual reality

, 2019
We compared three different Graphical User Interfaces (GUI) that we have designed and implemented to enable human supervision of an Autonomous Surface Vehicle (ASV).
Topp, Elin Anna, Lager, Mårten, Lager, Mårten,, Topp, Elin Anna,, Lund University.   +4 more
core   +2 more sources

Autonomous Mapping of Underwater Magnetic Fields Using a Surface Vehicle

IEEE Access, 2018
Geomagnetic field signals have potential for use in underwater navigation and geophysical surveys. To map underwater geomagnetic fields, we propose a method that exploits an autonomous surface vehicle. In our system, a magnetometer is rigidly attached to
Jongdae Jung, Jeonghong Park, Jinwoo Choi, Hyun-Taek Choi   +3 more
doaj   +1 more source

Intelligent functions development on autonomous electric vehicle platform [PDF]

, 2020
Autonomous driving is no longer just an idea of technology vision instead a real technical trend all over the world. The continuing development to a further level of autonomy requires more on mobile robots safety while bringing more challenges to human ...
Ruxin WANG, Ehsan MALAYJERDI, Wang, Ruxin, Sell, Raivo, Tauno OTTO, Rassolkin, Anton, Raivo SELL, Anton RASSOLKIN, Malayjerdi, Ehsan, Otto, Tauno   +9 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Towards Control of Autonomous Surface Vehicles in Rough Seas

IFAC-PapersOnLine, 2020
Abstract This paper addresses the problem of controlling an Autonomous Surface Vehicle (ASV) in rough sea-states, with a view towards minimising wave-induced forces, whilst maintaining headway. This is a challenging control application since, and as is derived in the paper, the interaction between the vessel and the wave disturbance is nonlinear and ...
McCullough, D.R., Jones, B., Villarreal, O.J.G., Rossiter, J.A.   +3 more
openaire   +2 more sources

Cooperative caging using autonomous aquatic surface vehicles [PDF]

2010 IEEE International Conference on Robotics and Automation, 2010
We present a study on the use of cooperative robots to execute a caging mission on the water's surface. In particular, we consider the problem of using two robotic boats (under-actuated autonomous surface vessels) connected with a floating rope, to ‘capture’ a floating object from a known location on the water's surface and 'shepherd' it to a ...
ARRICHIELLO, Filippo, HEIDARSSON H. K, CHIAVERINI, Stefano, SUKHATME G.   +3 more
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Naval Postgraduate School Center for Autonomous Underwater Vehicle Research / 2003 Annual Report [PDF]

, 2004
This report presents a summary of the work completed in 2003 at the NPS Center for Autonomous Underwater Vehicle (AUV) Research and provides a preview of future work planned for 2004.Approved for public release; distribution is unlimited ...
Kragelund, Sean
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source