Results 51 to 60 of about 6,125,993 (245)

External Force Field Modeling for Autonomous Surface Vehicles [PDF]

, 2020
In proceedings of International Symposium of Experimental Robotics (ISER ...
Jason Moulton, Nare Karapetyan, Alberto Quattrini Li, Ioannis M. Rekleitis   +3 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Collision-free Trajectory Planning for Autonomous Surface Vehicle [PDF]

2020 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM), 2020
In this paper, we propose an efficient and accurate method for autonomous surface vehicles to generate a smooth and collision-free trajectory considering its dynamics constraints. We decouple the trajectory planning problem as a front-end feasible path searching and a back-end kinodynamic trajectory optimization.
Licheng Wen, Jiaqing Yan, Xuemeng Yang, Yong Liu 0007, Yong Gu   +4 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Experimental evaluation of a hydrography surface vehicle in four navigation modes

Journal of Ocean Engineering and Science, 2017
Considering the effectiveness of maritime transportation, a large number of world's trade is carried by sea and ports. Monitoring ports and harbors are essential for 24 hourly loading/unloading of ships. In this regard, bathymetry and monitoring of depth
Hossein Mousazadeh, Jafarbiglu Hamid, Omrani Elham, Monhaseri Farshid, Kiapei Ali, Salmani-Zakaria Yousef, Makhsoos Ashkan   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

On Mixed-Initative Planning and Control for Autonomous Underwater Vehicles [PDF]

Supervision and control of Autonomous underwater vehicles (AUVs) has traditionally been focused on an operator determining a priori the sequence of waypoints of a single vehicle for a mission.
Chrpa, Lukáš, Py, Frederic, Ribeiro, Manuel, Pinto, Jose, Sousa, Joao, Rajan, Kanna   +5 more
core   +1 more source

Reactive Collision Avoidance of an Unmanned Surface Vehicle through Gaussian Mixture Model-Based Online Mapping

Journal of Marine Science and Engineering, 2022
With active research being conducted on maritime autonomous surface ships, it is becoming increasingly necessary to ensure the safety of unmanned surface vehicles (USVs). In this context, a key task is to correct their paths to avoid obstacles.
Dongwoo Lee, Joohyun Woo
doaj   +1 more source