Results 41 to 50 of about 1,007,449 (349)
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress
Autophagy, 2021 Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging negatively stranded enveloped RNA bunyavirus that causes SFTS with a high case fatality rate of up to 30%.
J. Yan +5 more
semanticscholar +1 more source
Autophagic flux is required for the synthesis of triacylglycerols and ribosomal protein turnover in Chlamydomonas [PDF]
, 2018 Autophagy is an intracellular catabolic process that allows cells to recycle unneeded or damaged material to maintain cellular homeostasis. This highly dynamic process is characterized by the formation of double-membrane vesicles called autophagosomes ...
Couso Liáñez, Inmaculada Concepción +4 more
core +1 more source
Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates [PDF]
Autophagy, 2015 Although numerous techniques have been developed to monitor autophagy and to probe its cellular functions, these methods cannot evaluate in sufficient detail the autophagy process, and suffer limitations from complex experimental setups and/or systematic errors.
Maulucci, Giuseppe +5 more
openaire +2 more sources
Journal of Cellular and Molecular Medicine, 2021 Cataracts are the leading cause of blindness worldwide owing to the increasing proportion of elderly individuals in the population. The purpose of this study was to investigate whether metformin could alleviate the occurrence and development of age ...
Mengmeng Chen +5 more
semanticscholar +1 more source
Why should autophagic flux be assessed? [PDF]
Acta Pharmacologica Sinica, 2013 As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders.
Xiao-jie, Zhang +3 more
openaire +2 more sources
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Autophagy, 2018 Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation.
Mario Mauthe +9 more
semanticscholar +1 more source
Cell Death and Disease, 2021 The biological function of TRIM39, a member of TRIM family, remains largely unexplored in cancer, especially in colorectal cancer (CRC). In this study, we show that TRIM39 is upregulated in tumor tissues compared to adjacent normal tissues and associated
Jia Hu +9 more
semanticscholar +1 more source
The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +1 more source
Biomedical Journal, 2022 Background: Stressed animals may perform depression-like behavior insomuch as stress-provoking blood–brain barrier (BBB) disruption, central immune activation, and autophagic flux changes.
Yi-Han Liao +6 more
doaj +1 more source
Cell communication and signaling : CCS, 2022 Background Percutaneous transluminal coronary angioplasty (PTCA) represents an efficient therapeutic method for atherosclerosis but conveys a risk of causing restenosis.
Xiao Ke +7 more
semanticscholar +1 more source