Results 61 to 70 of about 1,007,449 (349)
Acylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux
Frontiers in Pharmacology, 2021 Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and our previous study revealed that autophagic flux dysfunction contributes to the neuron death in 6-OHDA-induced PD models.
Xin He +4 more
semanticscholar +1 more source
Rapamycin induces autophagic flux in neurons [PDF]
Proceedings of the National Academy of Sciences, 2010 Autophagy is a bulk degradation process initiated when cells engulf cytoplasm (including organelles) within double-membraned vesicles, called autophagosomes, that ultimately fuse to lysosomes, where their contents are degraded. Despite extensive data showing that mammalian target of rapamycin (mTOR) kinase inhibition by rapamycin induces autophagy in ...
David C. Rubinsztein, Ralph A. Nixon
openaire +1 more source
Neurobiology of Disease, 2014 Niemann–Pick disease type C (NPC) is a fatal, progressive neurovisceral disorder. Several studies report that the autophagic flux is disturbed in NPC1-deficient (NPC1−/−) cells. Since it has been suggested that the autophagic defect may contribute to the
Volker Meske +3 more
doaj +1 more source
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes
Hepatology Communications, 2021 Lysosomes are intracellular acidic organelles with catabolic functions that contribute to the activation of autophagy. Although autophagy abnormality is associated with defects in lysosomal acidification during the progression of nonalcoholic fatty liver
Hyeon‐Ji Kim +3 more
semanticscholar +1 more source
Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]
, 2012 Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso +58 more
core +1 more source
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]
, 2020 Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro +12 more
core +1 more source
PLoS ONE, 2014 Epigallocatechin gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the impairment in learning and memory. Autophagy is a cellular process that protects neurons from stressful conditions.
Hong-Feng Gu +7 more
doaj +1 more source
Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]
, 2019 Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet +4 more
core +1 more source
Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]
, 2020 Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Cavadas, Cláudia +10 more
core +1 more source
Frontiers in Oncology, 2019 Although the cancer/testis antigen CAGE has been implicated in tumorigenesis, the molecular mechanisms of CAGE-promoted tumorigenesis remain largely unknown.
Minjeong Yeon +5 more
doaj +1 more source