Results 11 to 20 of about 87,330 (144)
Cells, 2023 Autophagy–the lysosomal degradation of cytoplasm–plays a central role in cellular homeostasis and protects cells from potentially harmful agents that may accumulate in the cytoplasm, including pathogens, protein aggregates, and dysfunctional organelles. This process is initiated by the formation of a phagophore membrane, which wraps around a portion of
Yan Zhen, Harald Stenmark
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Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 2021 The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion of FIP200 vesicles, derived from the cis-Golgi, with endosomally derived ...
Kumar, Suresh +21 more
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Journal of Molecular Biology, 2020 Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes. The process starts with the capture of unnecessary material into autophagosomes, which is followed by autophagosome-lysosome fusion to generate autolysosomes that degrade the ...
Lőrincz, Péter, Juhász, Gábor
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Measuring autophagosome flux [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a proteolytic pathway that is involved in both bulk degradation of cytoplasmic proteins as well as in selective degradation of cytoplasmic organelles. Autophagic flux is often defined as a measure of autophagic degradation activity, and many techniques exist to assess autophagic flux. Although these techniques have generated
Andre du Toit +3 more
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The EmERgence of Autophagosomes [PDF]
Developmental Cell, 2009 Autophagosomes are large double-membrane vesicles that enclose cytoplasmic components targeting them for degradation. Two recent reports reveal that phagophores, the autophagosome precursors, are surrounded by and connected to rough endoplasmic reticulum (ER) membranes.
Reggiori, Fulvio, Tooze, Sharon A
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ATPase-regulated autophagosome biogenesis
Autophagy, 2023 Omega-shaped domains of the endoplasmic reticulum, known as omegasomes, have been suggested to contribute to autophagosome biogenesis, although their exact function is not known. Omegasomes are characterized by the presence of the double FYVE domain containing protein ZFYVE1/DFCP1, but it has remained a paradox that depletion of ZFYVE1 does not prevent
Nähse, Viola +2 more
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Dynamics of Autophagosome Formation [PDF]
Plant Physiology, 2017 Environmental stress activates autophagy and leads to autophagosome formation at the endoplasmic reticulum.
Junmarie Soto-Burgos +3 more
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Molecular regulation of autophagosome formation [PDF]
Biochemical Society Transactions, 2022 Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative disorders.
Hu, Yan, Reggiori, Fulvio
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Mechanisms of Autophagosome Biogenesis [PDF]
Current Biology, 2012 Autophagy is a unique membrane trafficking process whereby newly formed membranes, termed phagophores, engulf parts of the cytoplasm leading to the production of double-membraned autophagosomes that get delivered to lysosomes for degradation. This catabolic pathway has been linked to numerous physiological and pathological conditions, such as ...
Rubinsztein, David C. +2 more
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Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]
, 2012 The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
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