Results 41 to 50 of about 73,321 (302)
The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy
Autophagy Reports, 2022 Macroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation ...
Franziska Kriegenburg +7 more
doaj +1 more source
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation [PDF]
, 2013 The membrane remodeling events required for autophagosome biogenesis are still poorly understood. Because PX domain proteins mediate membrane remodeling and trafficking, we conducted an imaging-based siRNA screen for autophagosome formation targeting ...
Søreng, Kristiane +26 more
core +1 more source
Toward a standard model for autophagosome biogenesis [PDF]
, 2023 Two papers in this issue resolve a long-standing obstacle to a "standard model" for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol.
Annan S.I. Cook +3 more
core +1 more source
Autophagosome formation machinery.
, 2023 (1) The initiation of autophagosome formation requires the activation of the ULK complex (composed of ULK1/2 (unc-51-like kinases 1 and 2), ATG13, ATG101, and FIP200 (also known as RB1CC1)), which further activates ATG13 inducing its translocation to the
Jérémy Verbeke (5396666) +2 more
core +1 more source
The Impact of Aging on Macroautophagy in the Pre-ovulatory Mouse Oocyte
Frontiers in Cell and Developmental Biology, 2021 Accompanying the precipitous age-related decline in human female fertility is an increase in the proportion of poor-quality oocytes within the ovary. The macroautophagy pathway, an essential protein degradation mechanism responsible for maintaining cell ...
Alexandra E. Peters +17 more
doaj +1 more source
The Intriguing Life of Autophagosomes [PDF]
International Journal of Molecular Sciences, 2012 Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the ...
Mijaljica, Dalibor +2 more
openaire +2 more sources
Pharmaceuticals, 2021 Polyphenols are a family of naturally occurring organic compounds, majorly present in fruits, vegetables, and cereals, characterised by multiple phenol units, including flavonoids, tannic acid, and ellagitannin.
James Michael Brimson +6 more
doaj +1 more source
Scaffolding the expansion of autophagosomes [PDF]
Autophagy, 2014 The conjugation of the small ubiquitin (Ub)-like protein Atg8 to autophagic membranes is a key step during the expansion of phagophores. This reaction is driven by 2 interconnected Ub-like conjugation systems. The second system conjugates the Ub-like protein Atg12 to Atg5.
Kaufmann, A., Wollert, T.
openaire +3 more sources
Molecular regulation of autophagosome formation [PDF]
, 2022 Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative ...
Hu, Yan, Reggiori, Fulvio
core +1 more source
Membrane supply and remodeling during autophagosome biogenesis [PDF]
, 2021 The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion ...
Gómez-Sánchez, Rubén +2 more
core +2 more sources