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Autophagosome biogenesis: From membrane growth to closure
, 2020 Autophagosome biogenesis involves de novo formation of a membrane that elongates to sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an autophagosome). This process has remained enigmatic since its initial discovery >50 yr
Melia, Thomas +2 more
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Membrane supply and remodeling during autophagosome biogenesis [PDF]
, 2021 The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion ...
Gómez-Sánchez, Rubén +2 more
core +3 more sources
MicroorganismsAutophagy is an essential eukaryotic catabolic process through which damaged or superfluous cellular components are degraded and recycled via the formation of double-membrane autophagosomes.
Sung Un Huh
doaj +1 more source
Oncolytic Myxoma virus Increases Autophagy in Multiple Myeloma
Turkish Journal of HematologyObjective: Multiple myeloma, which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level.
Alpay Yeşilaltay +2 more
doaj +1 more source
Assays to Monitor Autophagy Progression in Cell Cultures
Cells, 2017 The vast number of implications of autophagy in multiple areas of life sciences and medicine has attracted the interest of numerous scientists that aim to unveil the role of this process in specific physiological and pathological contexts.
Idil Orhon, Fulvio Reggiori
doaj +1 more source
Amphisomes: out of the autophagosome shadow? [PDF]
The EMBO Journal, 2013 Amphisomes are intermediate organelles, formed during autophagy through the fusion between autophagosomes and endosomes. Complex multivesicular vacuoles that resemble amphisomes have been observed in various cell types, but whether they have cellular roles other than being a precursor structure is still enigmatic. While autophagy-related (ATG) proteins
Sanchez-Wandelmer, Jana +1 more
openaire +3 more sources
Veterinary Research, 2022 Autophagy is an important conserved homeostatic process related to nutrient and energy deficiency and organelle damage in diverse eukaryotic cells and has been reported to play an important role in cellular responses to pathogens and bacterial ...
Yukang Wen +6 more
doaj +1 more source
The many uses of autophagosomes [PDF]
Autophagy, 2013 Autophagy has emerged as a significant innate immune response to pathogens. Typically, autophagosomes deliver their contents to lysosomes for degradation. Some pathogens such as Salmonella enterica serovar Typhimurium succumb to autophagy and are transported to lysosomes for degradation.
openaire +2 more sources
Autophagosome maturation in primary rat hepatocytes. [PDF]
, 2006 Nutrient deprivation of eukaryotic cells elicits a rapid survival response, including the induction of autophagy. Autophagy, or "self-eating", involves the formation of autophagosomes from an unknown membrane source and the sequestration of cytosolic ...
Kchl, R., Köchl, Robert
core
SRBSDV localized on the autophagosome membrane.
, 2023 (A) TEM of viruliferous WBPH midgut epithelial cells containing autophagosome-like double-membrane structures surrounded by immature and mature SRBSDV virions. Red arrow: immature SRBSDV virions; black arrow: mature SRBSDV virions.
Xifeng Wang (230804) +6 more
core +1 more source