Results 51 to 60 of about 73,321 (302)

Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes

Cell, 2021
The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion of FIP200 vesicles, derived from the cis-Golgi, with endosomally derived ...
Kumar, Suresh, Javed, Ruheena, Mudd, Michal, Pallikkuth, Sandeep, Lidke, Keith A, Jain, Ashish, Tangavelou, Karthikeyan, Gudmundsson, Sigurdur Runar, Ye, Chunyan, Rusten, Tor Erik, Anonsen, Jan Haug, Lystad, Alf Håkon, Claude-Taupin, Aurore, Simonsen, Anne, Salemi, Michelle, Phinney, Brett, Li, Jing, Guo, Lian-Wang, Bradfute, Steven B, Timmins, Graham S, Eskelinen, Eeva-Liisa, Deretic, Vojo   +21 more
openaire   +5 more sources

Autophagosome biogenesis: From membrane growth to closure

, 2020
Autophagosome biogenesis involves de novo formation of a membrane that elongates to sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an autophagosome). This process has remained enigmatic since its initial discovery >50 yr
Melia, Thomas, Simonsen, Anne, Lystad, Alf Håkon   +2 more
core   +1 more source

ER-driven membrane contact sites: Evolutionary conserved machineries for stress response and autophagy regulation?

Communicative & Integrative Biology, 2017
Endoplasmic Reticulum (ER), spreading in the whole cell cytoplasm, is a central player in eukaryotic cell homeostasis, from plants to mammals. Beside crucial functions, such as membrane lipids and proteins synthesis and outward transport, the ER is able ...
Diana Molino, Anna Chiara Nascimbeni, Francesca Giordano, Patrice Codogno, Etienne Morel   +4 more
doaj   +1 more source

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

eLife, 2013
Autophagy is a catabolic process for bulk degradation of cytosolic materials mediated by double-membraned autophagosomes. The membrane determinant to initiate the formation of autophagosomes remains elusive.
Liang Ge, David Melville, Min Zhang, Randy Schekman   +3 more
doaj   +1 more source

The Plant Homeodomain Protein Clp1 Regulates Fungal Development, Virulence, and Autophagy Homeostasis in Magnaporthe oryzae

Microbiology Spectrum, 2022
Rice blast disease caused by Magnaporthe oryzae is a serious threat to global grain yield and food security. Cti6 is a nuclear protein containing a plant homeodomain (PHD) that is involved in transcriptional regulation in Saccharomyces cerevisiae.
Jing Wang, Zhicheng Huang, Pengyun Huang, Qing Wang, Yan Li, Xiao-Hong Liu, Fu-Cheng Lin, Jianping Lu   +7 more
doaj   +1 more source

SRBSDV localized on the autophagosome membrane.

, 2023
(A) TEM of viruliferous WBPH midgut epithelial cells containing autophagosome-like double-membrane structures surrounded by immature and mature SRBSDV virions. Red arrow: immature SRBSDV virions; black arrow: mature SRBSDV virions.
Xifeng Wang (230804), Hui Wang (30400), Lu Zhang (50563), Yule Liu (159803), Wenwen Liu (195246), Zhongkai Zhang (343854), Nan Wu (200090)   +6 more
core   +1 more source

Interaction of Potato Autophagy-Related StATG8 Family Proteins with Pathogen Effector and WRKY Transcription Factor in the Nucleus

Microorganisms
Autophagy is an essential eukaryotic catabolic process through which damaged or superfluous cellular components are degraded and recycled via the formation of double-membrane autophagosomes.
Sung Un Huh
doaj   +1 more source

Parkin mitochondria in the autophagosome [PDF]

The Journal of Cell Biology, 2008
Narendra et al. (see p. 795 of this issue) have made an exciting new discovery that links the fields of mitochondrial quality control and the genetics of Parkinson's disease (PD). Through an elegant series of high-resolution imaging experiments, they are the first to provide evidence that the PARK2 gene product Parkin is selectively recruited to ...
openaire   +2 more sources

Oncolytic Myxoma virus Increases Autophagy in Multiple Myeloma

Turkish Journal of Hematology
Objective: Multiple myeloma, which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level.
Alpay Yeşilaltay, Dilek Muz, Berna Erdal   +2 more
doaj   +1 more source

Assays to Monitor Autophagy Progression in Cell Cultures

Cells, 2017
The vast number of implications of autophagy in multiple areas of life sciences and medicine has attracted the interest of numerous scientists that aim to unveil the role of this process in specific physiological and pathological contexts.
Idil Orhon, Fulvio Reggiori
doaj   +1 more source