The critical role of dysregulated autophagy in the progression of diabetic kidney disease
Frontiers in Pharmacology, 2022 Diabetic kidney disease (DKD) is one of the major public health problems in society today. It is a renal complication caused by diabetes mellitus with predominantly microangiopathy and is a major cause of end-stage renal disease (ESRD).
Ziwei Zhang +8 more
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Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life [PDF]
, 2012 Accumulations of autophagosomes and non-esterified cholesterol are observed in several cell lines derived from lysosomal storage diseases, including Niemann Pick Type C (NPC).
Kleinman, Miriam Devorah
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Frontiers in Plant Science, 2020 Vesicle trafficking between the membrane-bound organelles in plant cells plays crucial roles in the precise transportation of various materials, and thus supports cell proliferation and cellular polarization.
Shuai Hu, Yan Li, Jinbo Shen
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Frontiers in Immunology, 2022 Neutrophils play major roles against bacteria and fungi infections not only due to their microbicide properties but also because they release mediators like Interleukin-1 beta (IL-1β) that contribute to orchestrate the inflammatory response.
Irene A. Keitelman +21 more
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OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation [PDF]
Journal of Cell Biology, 2011 Macroautophagy is a bulk degradation system conserved in all eukaryotic cells. A ubiquitin-like protein, Atg8, and its homologues are essential for autophagosome formation and act as a landmark for selective autophagy of aggregated proteins and damaged organelles.
Itoh, Takashi +4 more
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ATPase-regulated autophagosome biogenesis
Autophagy, 2023 Omega-shaped domains of the endoplasmic reticulum, known as omegasomes, have been suggested to contribute to autophagosome biogenesis, although their exact function is not known. Omegasomes are characterized by the presence of the double FYVE domain containing protein ZFYVE1/DFCP1, but it has remained a paradox that depletion of ZFYVE1 does not prevent
Nähse, Viola +2 more
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bpV(pic) reduces neuronal autophagosome aggregation.
, 2012 Vehicle-treated rats exhibited dense intracellular LC3-positive autophagosome aggregation in neurons (arrows). Treatment with bpV promoted a decrease in neuronal autophagosome clustering. n = 3. Scale bar = 50 µm.
Xiao-Ming Xu (188852) +6 more
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Lysosomal Dysfunction: Connecting the Dots in the Landscape of Human Diseases
BiologyLysosomes are the main organelles responsible for the degradation of macromolecules in eukaryotic cells. Beyond their fundamental role in degradation, lysosomes are involved in different physiological processes such as autophagy, nutrient sensing, and ...
Elisabet Uribe-Carretero +3 more
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E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I [PDF]
, 2013 p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
Wang, W +17 more
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Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation
eLifeDuring macroautophagy, cytoplasmic constituents are engulfed by autophagosomes. Lysosomes fuse with closed autophagosomes but not with unclosed intermediate structures. This is achieved in part by the late recruitment of the autophagosomal SNARE syntaxin
Saori Shinoda +7 more
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