Results 71 to 80 of about 77,404 (202)
The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases
Membranes, 2012 Eukaryotic cells have complicated membrane systems. The outermost plasma membrane contains various substructures, such as invaginations and protrusions, which are involved in endocytosis and cell migration.
Fatemeh Safari, Shiro Suetsugu
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Accumulation of autophagosomes confers cytotoxicity [PDF]
Journal of Biological Chemistry, 2017 Autophagy comprises the processes of autophagosome synthesis and lysosomal degradation. In certain stress conditions, increased autophagosome synthesis may be associated with decreased lysosomal activity, which may result in reduced processing of the excessive autophagosomes by the rate-limiting lysosomal activity. Thus, the excessive autophagosomes in
Button, Robert W. +4 more
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Dynamics of Autophagosome Formation [PDF]
, 2018 Autophagy, literally defined as “self-eating,” functions as a degradation process by recycling cytoplasmic contents under stress conditions or during development. Upon activation of autophagy, a membrane structure known as a phagophore forms and expands,
Bassham, Diane +3 more
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Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae [PDF]
, 2007 Autophagy is a degradation process accompanied by dynamic membrane organization. In the yeast, Saccharomyces cerevisiae, about 30 ATG (autophagy-related) genes have been identified as important genes for autophagy.
Ohsumi, Yoshinori, Suzuki, Kuninori
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A SPONTANEOUS MOUSE MODEL OF X-LINKED MYOPATHY WITH EXCESSIVE AUTOPHAGY [PDF]
, 2011 the subject of the thesis research project, aims to characterize a murine model for spontaneous muscle pathology comparable to human "X-Linked Vacuolar myopathy with Excessive Autophagy (XMEA)".
Iovane, Valentina
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eLifeA change in the electric charge of autophagosome membranes controls the recruitment of SNARE proteins to ensure that membrane fusion occurs at the right time during autophagy.
Zhiqi Tian, Jiajie Diao
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Parkin mitochondria in the autophagosome [PDF]
The Journal of Cell Biology, 2008 Narendra et al. (see p. 795 of this issue) have made an exciting new discovery that links the fields of mitochondrial quality control and the genetics of Parkinson's disease (PD). Through an elegant series of high-resolution imaging experiments, they are the first to provide evidence that the PARK2 gene product Parkin is selectively recruited to ...
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A novel autophagy inhibitor, bTBT, disturbs autophagosome formation
, 2023 Macroautophagy (hereafter, autophagy) is a form of intracellular degradation in which autophagosome formation is systematically coordinated by multiple processes involving numerous autophagy-related gene (ATG) proteins. Autophagy-modulating compounds are
Tetsuhiro Nemoto +6 more
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Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells
CellsIn eukaryotes, targeting intracellular components for lysosomal degradation by autophagy represents a catabolic process that evolutionarily regulates cellular homeostasis.
Po-Yuan Ke
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The plant unique ESCRT component FREE1 regulates autophagosome closure
, 2023 Nutrient sensing impinges on the autophagosome biogenesis. Here, the authors present evidence that plant energy sensing regulates the autophagosome closure by modulating the phosphorylation status and localization of the ESCRT ...
Wenhan Cao +17 more
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