Results 91 to 100 of about 77,404 (202)
Multifunctional Roles of Autophagy in Fungi
Journal of FungiAutophagy, also referred to as the “self-eating machinery”, is a crucial process where organisms maintain intracellular homeostasis through recycling or degrading non-essential and damaged cellular components.
Aron Osakina +2 more
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The autophagosome is overrated! [PDF]
Autophagy, 2011 For some people, the appearance of autophagosomes by electron microscopy is the “gold standard” for demonstrating macroautophagy. I could quibble with this idea for various technical reasons. For example, just how many autophagosomes are needed per cell to truly indicate an increase in autophagy, and how often do people carry out morphometric analyses ...
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CellsLncRNA NR_003508 has been implicated in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome. Yet, the involvement of LncRNA NR_003508 in Pseudomonas aeruginosa (PA)-induced autophagy remains elusive.
Li Liu +3 more
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Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)
, 2011 The class III phosphatidylinositol 3-kinase (PI3KC3) is crucial for autophagosome biogenesis. It has been long speculated to nucleate the autophagosome membrane, but the biochemical mechanism of such nucleation activity remains unsolved.
Ashley Nassiri, Weiliang Fan, Qing Zhong
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Phospholipids in Autophagosome Formation and Fusion [PDF]
, 2016 Autophagosomes are double-membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation.
Nakamura, Shuhei +2 more
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Bitter Taste Receptor T2R14 and Autophagy Flux in Gingival Epithelial Cells
CellsMacroautophagy (hereafter autophagy) is a lysosomal degradation pathway that functions in nutrient recycling and as a mechanism of innate immunity. Previously, we reported a novel host–bacteria interaction between cariogenic S.
Nisha Singh +6 more
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Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity
Toxics, 2015 The transition metal ion cadmium (Cd2+) is a significant environmental contaminant. With a biological half-life of ~20 years, Cd2+ accumulates in the kidney cortex, where it particularly damages proximal tubule (PT) cells and can result in renal fibrosis,
Frank Thévenod, Wing-Kee Lee
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Coronavirus NSP6 restricts autophagosome expansion
, 2014 Autophagy is a cellular response to starvation that generates autophagosomes to carry long-lived proteins and cellular organelles to lysosomes for degradation. Activation of autophagy by viruses can provide an innate defense against infection, and for (+)
Cottam, Eleanor +2 more
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Unconventional secretion by autophagosome exocytosis [PDF]
Journal of Cell Biology, 2010 In this issue, Duran et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911154) and Manjithaya et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911149) use yeast genetics to reveal a role for autophagosome intermediates in the unconventional secretion of an acyl coenzyme A (CoA)–binding protein that lacks an endoplasmic reticulum signal sequence.
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Atg41/Icy2 regulates autophagosome formation
, 2016 Macroautophagy (hereafter autophagy) is one of the major degradation systems in eukaryotic cells, and its dysfunction may result in diseases ranging from neurodegeneration to cancer.
Steven K Backues (3237315) +3 more
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