Results 81 to 90 of about 77,404 (202)
The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease
Frontiers in EndocrinologyNon-alcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome characterized by excessive fat deposition in hepatocytes and a major cause of end-stage liver disease.
Qiaohui Shen +9 more
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Frontiers in Microbiology, 2018 Autophagy is an essential process for cellular metabolism and homeostasis, but also functions as one of innate immune responses against pathogen infection.
Takahiro Kuroki +4 more
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New insights into autophagosome–lysosome fusion
, 2017 Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic targets of autophagy, its dysregulation is associated with many diseases ...
Tamotsu Yoshimori, Shuhei Nakamura
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Membrane dynamics in autophagosome biogenesis
, 2015 Bilayered phospholipid membranes are vital to the organization of the living cell. Based on fundamental principles of polarity, membranes create borders allowing defined spaces to be encapsulated.
Simonsen, Anne, Carlsson, Sven R,
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Vac8 spatially confines autophagosome formation at the vacuole [PDF]
, 2019 Autophagy is initiated by the formation of phagophore assembly sites (PAS), the precursors of autophagosomes. In mammals, PAS form throughout the cytosol in specialized subdomains of the endoplasmic reticulum (ER).
Kriegenburg, Franziska +9 more
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Recent Advances in Membrane Shaping for Plant Autophagosome Biogenesis
Frontiers in Plant Science, 2020 Autophagy is an intracellular degradation process, which is highly conserved in eukaryotes. During this process, unwanted cytosolic constituents are sequestered and delivered into the vacuole/lysosome by a double-membrane organelle known as an ...
Cheuk-Ling Wun +2 more
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Herpesviruses and Autophagy: Catch Me If You Can!
Viruses, 2010 Autophagy is an evolutionarily conserved cellular degradation pathway involving the digestion of intracellular components via the lysosomal pathway. The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles ...
Audrey Esclatine, Yolaine Cavignac
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MicroorganismsHepatitis E virus (HEV) is a zoonotic pathogen that can infect pregnant women and cause adverse pregnancy outcomes, including miscarriage and preterm delivery.
Yinzhu Chen +6 more
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Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion
eLife, 2015 Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells.
Min Zhang +4 more
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The Journal of Cell Biology, 2006 An understanding of de novo organelle construction comes one step closer thanks to He et al. (page [925][1]), who find that Atg11 leads Atg9 to the preautophagosomal structure (PAS). The PAS is intriguing because it is the site where fragments of membrane coalesce to form a new organelle ...
openaire +1 more source