Results 111 to 120 of about 73,321 (302)
Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)
, 2011 The class III phosphatidylinositol 3-kinase (PI3KC3) is crucial for autophagosome biogenesis. It has been long speculated to nucleate the autophagosome membrane, but the biochemical mechanism of such nucleation activity remains unsolved.
Ashley Nassiri, Weiliang Fan, Qing Zhong
core +1 more source
Advanced Science, EarlyView.TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang +12 more
wiley +1 more source
Recent Advances in Membrane Shaping for Plant Autophagosome Biogenesis
Frontiers in Plant Science, 2020 Autophagy is an intracellular degradation process, which is highly conserved in eukaryotes. During this process, unwanted cytosolic constituents are sequestered and delivered into the vacuole/lysosome by a double-membrane organelle known as an ...
Cheuk-Ling Wun +2 more
doaj +1 more source
Advanced Science, EarlyView.Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen +8 more
wiley +1 more source
Herpesviruses and Autophagy: Catch Me If You Can!
Viruses, 2010 Autophagy is an evolutionarily conserved cellular degradation pathway involving the digestion of intracellular components via the lysosomal pathway. The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles ...
Audrey Esclatine, Yolaine Cavignac
doaj +1 more source
Advanced Science, EarlyView.NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang +12 more
wiley +1 more source
Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion
eLife, 2015 Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells.
Min Zhang +4 more
doaj +1 more source
The Journal of Cell Biology, 2006 An understanding of de novo organelle construction comes one step closer thanks to He et al. (page [925][1]), who find that Atg11 leads Atg9 to the preautophagosomal structure (PAS). The PAS is intriguing because it is the site where fragments of membrane coalesce to form a new organelle ...
openaire +1 more source
Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae
, 2007 Autophagy is a degradation process accompanied by dynamic membrane organization. In the yeast, Saccharomyces cerevisiae, about 30 ATG (autophagy-related) genes have been identified as important genes for autophagy.
Ohsumi, Yoshinori, Suzuki, Kuninori
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Leishmania-induced autophagosome-associated proteins (M).
, 2023 Leishmania-induced autophagosome-associated proteins (M).
Kyung-Mee Moon (685480) +5 more
core +1 more source