Results 31 to 40 of about 77,404 (202)
Autophagosome formation machinery.
, 2023 (1) The initiation of autophagosome formation requires the activation of the ULK complex (composed of ULK1/2 (unc-51-like kinases 1 and 2), ATG13, ATG101, and FIP200 (also known as RB1CC1)), which further activates ATG13 inducing its translocation to the
Jérémy Verbeke (5396666) +2 more
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Pharmaceuticals, 2021 Polyphenols are a family of naturally occurring organic compounds, majorly present in fruits, vegetables, and cereals, characterised by multiple phenol units, including flavonoids, tannic acid, and ellagitannin.
James Michael Brimson +6 more
doaj +1 more source
Toward a standard model for autophagosome biogenesis [PDF]
, 2023 Two papers in this issue resolve a long-standing obstacle to a "standard model" for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol.
Annan S.I. Cook +3 more
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Scaffolding the expansion of autophagosomes [PDF]
Autophagy, 2014 The conjugation of the small ubiquitin (Ub)-like protein Atg8 to autophagic membranes is a key step during the expansion of phagophores. This reaction is driven by 2 interconnected Ub-like conjugation systems. The second system conjugates the Ub-like protein Atg12 to Atg5.
Kaufmann, A., Wollert, T.
openaire +3 more sources
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 2021 The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion of FIP200 vesicles, derived from the cis-Golgi, with endosomally derived ...
Kumar, Suresh +21 more
openaire +5 more sources
Autophagosome Formation: Tracing the Source [PDF]
, 2013 Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial ...
Klionsky, Daniel J., Bernard, Amélie
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Communicative & Integrative Biology, 2017 Endoplasmic Reticulum (ER), spreading in the whole cell cytoplasm, is a central player in eukaryotic cell homeostasis, from plants to mammals. Beside crucial functions, such as membrane lipids and proteins synthesis and outward transport, the ER is able ...
Diana Molino +4 more
doaj +1 more source
eLife, 2013 Autophagy is a catabolic process for bulk degradation of cytosolic materials mediated by double-membraned autophagosomes. The membrane determinant to initiate the formation of autophagosomes remains elusive.
Liang Ge +3 more
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Microbiology Spectrum, 2022 Rice blast disease caused by Magnaporthe oryzae is a serious threat to global grain yield and food security. Cti6 is a nuclear protein containing a plant homeodomain (PHD) that is involved in transcriptional regulation in Saccharomyces cerevisiae.
Jing Wang +7 more
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Molecular regulation of autophagosome formation [PDF]
, 2022 Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative ...
Hu, Yan, Reggiori, Fulvio
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