Results 31 to 40 of about 73,321 (302)

Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome–vacuole fusion [PDF]

Journal of Cell Biology, 2018
Autophagy mediates the bulk degradation of cytoplasmic material, particularly during starvation. Upon the induction of autophagy, autophagosomes form a sealed membrane around cargo, fuse with a lytic compartment, and release the cargo for degradation.
Levent Bas, Daniel Papinski, Mariya Licheva, Raffaela Torggler, Sabrina Rohringer, Martina Schuschnig, Claudine Kraft   +6 more
openaire   +4 more sources

Phospholipid imbalance impairs autophagosome completion [PDF]

, 2022
Autophagy, a conserved eukaryotic intracellular catabolic pathway, maintains cell homeostasis by lysosomal degradation of cytosolic material engulfed in double membrane vesicles termed autophagosomes, which form upon sealing of single‐membrane cisternae ...
Milana Fraiberg, Chao Qin, Zvulun Elazar, Mari, Muriel, Shimoni, Eyal, Reggiori, Fulvio M, Muriel Mari, Qin, Chao, Fraiberg, Milana, Dadosh, Tali, Shatz, Oren, Oren Shatz, Eyal Shimoni, Fulvio M Reggiori, Han, Xianlin, Elazar, Zvulun, Tali Dadosh, Alexandra Polyansky, Polyansky, Alexandra, Xianlin Han   +19 more
core   +1 more source

The Autophagy-Related Gene Aolatg4 Regulates Hyphal Growth, Sporulation, Autophagosome Formation, and Pathogenicity in Arthrobotrys oligospora

Frontiers in Microbiology, 2020
Autophagy plays an important role in cell growth and development. The autophagy-related gene atg4 encodes a cysteine protease, which can cleave the carboxyl terminus of Atg8, thus plays a role in autophagosome formation in yeast and filamentous fungi ...
Duanxu Zhou, Meihua Xie, Na Bai, Le Yang, Ke-Qin Zhang, Jinkui Yang   +5 more
doaj   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
Williams, Roderick A M, Mottram, Jeremy C, Roderick A M Williams, Benjamin Cull, Mottram Jeremy C., Coombs, Graham H, Williams Roderick A. M., Cull Benjamin, Terry K Smith, Jeremy C. Mottram (112563), Graham H. Coombs (164011), Smith Terry K., Terry K. Smith (112550), Mottram, Jeremy C., Benjamin Cull (164010), Coombs Graham H., Coombs, Graham H., Smith, Terry K., Jeremy C Mottram, Smith, Terry K, Cull, Benjamin, Williams, Roderick A. M., Roderick A. M. Williams (164005), Graham H Coombs   +23 more
core   +1 more source

Tracking autophagy during proliferation and differentiation of trypanosoma brucei [PDF]

, 2014
Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Proto, William R., Jones, Nathaniel G., Mottram, Jeremy, Jones, N.G., Coombs, Graham, Mottram, Jeremy C., Coombs, Graham H., Proto, William R   +7 more
core   +1 more source

Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis

Cells, 2022
Environmental noise is a common hazard in military operations. Military service members during long operations are often exposed to around-the-clock noise and suffer massive emotional and cognitive dysfunction related to an Alzheimer’s disease (AD)-like ...
Pengfang Zheng, Xiaojun She, Chunping Wang, Yingwen Zhu, Bo Fu, Kefeng Ma, Honglian Yang, Xiujie Gao, Xiaofang Li, Fangshan Wu, Bo Cui   +10 more
doaj   +1 more source

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila [PDF]

, 2008
Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3)) – kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear.
Backer, J. M., Baehrecke, EH, Miklós Sass, Hill, JH, Ying Yan, Hill, J. H., Sass, Miklós, Jahda H. Hill, Backer, JM, Gábor Juhász, Thomas P. Neufeld, Jonathan M. Backer, Baehrecke, E. H., Yan, Y, Neufeld, TP, Juhász, Gábor, Yan, Y., Neufeld, T. P., Eric H. Baehrecke   +18 more
core   +1 more source

Origin of the Autophagosomal Membrane in Plants

Frontiers in Plant Science, 2016
During autophagy, cargo molecules destined for degradation are sequestrated into a double membrane structure called autophagosome, which subsequently fuses with the vacuole.
Xiaohong Zhuang, Kin Pan CHUNG, Liwen Jiang, Liwen Jiang   +3 more
doaj   +1 more source

IFIT3 and IFIT5 Play Potential Roles in Innate Immune Response of Porcine Pulmonary Microvascular Endothelial Cells to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

Viruses, 2022
Our previous study has demonstrated that porcine pulmonary microvascular endothelial cells (MVECs) are susceptible to highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV).
Yanmei Wu, Xiaoxiao Song, Defeng Cui, Tao Zhang   +3 more
doaj   +1 more source

Autophagy and the (pro)renin receptor

Frontiers in Endocrinology, 2013
The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
doaj   +1 more source