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Mechanisms of autophagosome formation
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesThe formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis.
Yuko FUJIOKA, Nobuo N. NODA
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The EmERgence of Autophagosomes [PDF]
Developmental Cell, 2009 Autophagosomes are large double-membrane vesicles that enclose cytoplasmic components targeting them for degradation. Two recent reports reveal that phagophores, the autophagosome precursors, are surrounded by and connected to rough endoplasmic reticulum (ER) membranes.
Reggiori, Fulvio, Tooze, Sharon A
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Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes [PDF]
Traffic, 2005 Nutrient deprivation of eukaryotic cells provokes a variety of stress responses, including autophagy. Autophagy is carried out by autophagosomes which sequester cytosolic components and organelles for degradation after fusion with protease‐containing endosomes.
Köchl, Robert +3 more
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Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation [PDF]
Molecular Biology of the Cell, 2008 Autophagy induced by nutrient depletion is involved in survival during starvation conditions. In addition to starvation-induced autophagy, the yeast Saccharomyces cerevisiae also has a constitutive autophagy-like system, the Cvt pathway. Among 31 autophagy-related (Atg) proteins, the function of Atg17, Atg29, and Atg31 is required specifically for ...
Tomoko Kawamata +4 more
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Mechanisms of Autophagosome Biogenesis [PDF]
Current Biology, 2012 Autophagy is a unique membrane trafficking process whereby newly formed membranes, termed phagophores, engulf parts of the cytoplasm leading to the production of double-membraned autophagosomes that get delivered to lysosomes for degradation. This catabolic pathway has been linked to numerous physiological and pathological conditions, such as ...
Rubinsztein, David C. +2 more
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Dynamics of Autophagosome Formation [PDF]
Plant Physiology, 2017 Environmental stress activates autophagy and leads to autophagosome formation at the endoplasmic reticulum.
Junmarie Soto-Burgos +3 more
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Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome–vacuole fusion [PDF]
Journal of Cell Biology, 2018 Autophagy mediates the bulk degradation of cytoplasmic material, particularly during starvation. Upon the induction of autophagy, autophagosomes form a sealed membrane around cargo, fuse with a lytic compartment, and release the cargo for degradation.
Levent Bas +6 more
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Origin of the Autophagosomal Membrane in Plants
Frontiers in Plant Science, 2016 During autophagy, cargo molecules destined for degradation are sequestrated into a double membrane structure called autophagosome, which subsequently fuses with the vacuole.
Xiaohong Zhuang +3 more
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Viruses, 2022 Our previous study has demonstrated that porcine pulmonary microvascular endothelial cells (MVECs) are susceptible to highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV).
Yanmei Wu +3 more
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Autophagy and the (pro)renin receptor
Frontiers in Endocrinology, 2013 The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
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