Results 11 to 20 of about 73,321 (302)
Cells, 2023 Autophagy–the lysosomal degradation of cytoplasm–plays a central role in cellular homeostasis and protects cells from potentially harmful agents that may accumulate in the cytoplasm, including pathogens, protein aggregates, and dysfunctional organelles ...
Yan Zhen, Harald Stenmark
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Journal of Molecular Biology, 2020 Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes. The process starts with the capture of unnecessary material into autophagosomes, which is followed by autophagosome-lysosome fusion to generate autolysosomes that degrade the ...
Peter Lőrincz, Gabor Juhasz
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Measuring autophagosome flux [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a proteolytic pathway that is involved in both bulk degradation of cytoplasmic proteins as well as in selective degradation of cytoplasmic organelles. Autophagic flux is often defined as a measure of autophagic degradation activity, and many techniques exist to assess autophagic flux. Although these techniques have generated
Andre du Toit +3 more
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Mechanisms of autophagosome formation
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesThe formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis.
Yuko FUJIOKA, Nobuo N. NODA
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Autophagosome Maturation and Fusion [PDF]
Journal of Molecular Biology, 2017 Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related ...
Reggiori, Fulvio, Ungermann, Christian
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Key Regulators of Autophagosome Closure
Cells, 2021 Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation.
Wenyan Jiang +6 more
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Autophagosome Formation: Tracing the Source [PDF]
Developmental Cell, 2013 Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al.
Bernard, Amélie, Klionsky, Daniel J.
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Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes [PDF]
Traffic, 2005 Nutrient deprivation of eukaryotic cells provokes a variety of stress responses, including autophagy. Autophagy is carried out by autophagosomes which sequester cytosolic components and organelles for degradation after fusion with protease‐containing endosomes.
Köchl, Robert +3 more
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Multifunctional Roles of Autophagy in Fungi [PDF]
Journal of FungiAutophagy, also referred to as the “self-eating machinery”, is a crucial process where organisms maintain intracellular homeostasis through recycling or degrading non-essential and damaged cellular components.
Aron Osakina +2 more
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Autophagosome Formation in Mammalian Cells.
Cell Structure and Function, 2002 Macroautophagy is an intracellular degradation system for the majority of proteins and some organelles. The molecular mechanism of autophagy has been extensively studied using the yeast, Saccharomyces cerevisiae, during these past 10 years. These studies suggested that the molecular machinery of autophagosome formation is well conserved from yeast to ...
Noboru Mizushima +2 more
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