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Phospholipids in Autophagosome Formation and Fusion
Journal of Molecular Biology, 2016 Autophagosomes are double membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation. Autophagosomes are formed in a de novo manner and are the result of substantial membrane remodeling processes involving numerous protein-lipid interactions.
Martens, Sascha +2 more
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The EmERgence of Autophagosomes [PDF]
Developmental Cell, 2009 Autophagosomes are large double-membrane vesicles that enclose cytoplasmic components targeting them for degradation. Two recent reports reveal that phagophores, the autophagosome precursors, are surrounded by and connected to rough endoplasmic reticulum (ER) membranes.
Reggiori, Fulvio, Tooze, Sharon A
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Frontiers in Immunology, 2021 Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly recognized as a critical process
Ainhoa Plaza-Zabala +6 more
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Frontiers in Cell and Developmental Biology, 2021 The exact relationships and detailed mechanisms between autophagy and necroptosis remain obscure. Here, we demonstrated the link between accumulated autophagosome and necroptosis by intervening with autophagic flux.
Yao Huang +12 more
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Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery
Cell Reports, 2020 Summary: Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases.
Carlos M. Guardia +10 more
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Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation [PDF]
Molecular Biology of the Cell, 2008 Autophagy induced by nutrient depletion is involved in survival during starvation conditions. In addition to starvation-induced autophagy, the yeast Saccharomyces cerevisiae also has a constitutive autophagy-like system, the Cvt pathway. Among 31 autophagy-related (Atg) proteins, the function of Atg17, Atg29, and Atg31 is required specifically for ...
Tomoko Kawamata +4 more
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HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation
Frontiers in Cell and Developmental Biology, 2020 Odontoblast differentiation is an important process during tooth development in which pre-odontoblasts undergo elongation, polarization, and finally become mature secretory odontoblasts.
Yunyan Zhan +4 more
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Mechanisms of Autophagosome Biogenesis [PDF]
Current Biology, 2012 Autophagy is a unique membrane trafficking process whereby newly formed membranes, termed phagophores, engulf parts of the cytoplasm leading to the production of double-membraned autophagosomes that get delivered to lysosomes for degradation. This catabolic pathway has been linked to numerous physiological and pathological conditions, such as ...
Rubinsztein, David C. +2 more
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Dynamics of Autophagosome Formation [PDF]
Plant Physiology, 2017 Environmental stress activates autophagy and leads to autophagosome formation at the endoplasmic reticulum.
Junmarie Soto-Burgos +3 more
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Membrane Contact Sites and Organelles Interaction in Plant Autophagy
Frontiers in Plant Science, 2020 Autophagy is an intracellular trafficking and degradation system for recycling of damaged organelles, mis-folded proteins and cytoplasmic constituents. Autophagy can be divided into non-selective autophagy and selective autophagy according to the cargo ...
Hao Ye +5 more
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