Results 21 to 30 of about 77,404 (202)

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila [PDF]

, 2008
Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3)) – kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear.
Backer, J. M., Baehrecke, EH, Miklós Sass, Hill, JH, Ying Yan, Hill, J. H., Sass, Miklós, Jahda H. Hill, Backer, JM, Gábor Juhász, Thomas P. Neufeld, Jonathan M. Backer, Baehrecke, E. H., Yan, Y, Neufeld, TP, Juhász, Gábor, Yan, Y., Neufeld, T. P., Eric H. Baehrecke   +18 more
core   +1 more source

IFIT3 and IFIT5 Play Potential Roles in Innate Immune Response of Porcine Pulmonary Microvascular Endothelial Cells to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

Viruses, 2022
Our previous study has demonstrated that porcine pulmonary microvascular endothelial cells (MVECs) are susceptible to highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV).
Yanmei Wu, Xiaoxiao Song, Defeng Cui, Tao Zhang   +3 more
doaj   +1 more source

Phospholipid imbalance impairs autophagosome completion [PDF]

, 2022
Autophagy, a conserved eukaryotic intracellular catabolic pathway, maintains cell homeostasis by lysosomal degradation of cytosolic material engulfed in double membrane vesicles termed autophagosomes, which form upon sealing of single‐membrane cisternae ...
Milana Fraiberg, Chao Qin, Zvulun Elazar, Mari, Muriel, Shimoni, Eyal, Reggiori, Fulvio M, Muriel Mari, Qin, Chao, Fraiberg, Milana, Dadosh, Tali, Shatz, Oren, Oren Shatz, Eyal Shimoni, Fulvio M Reggiori, Han, Xianlin, Elazar, Zvulun, Tali Dadosh, Alexandra Polyansky, Polyansky, Alexandra, Xianlin Han   +19 more
core   +2 more sources

Autophagy and the (pro)renin receptor

Frontiers in Endocrinology, 2013
The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
doaj   +1 more source

The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy

Autophagy Reports, 2022
Macroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation ...
Franziska Kriegenburg, Wouter Huiting, Fleur van Buuren-Broek, Emma Zwilling, Ralph Hardenberg, Muriel Mari, Claudine Kraft, Fulvio Reggiori   +7 more
doaj   +1 more source

Modeling Membrane Morphological Change during Autophagosome Formation [PDF]

, 2020
Summary Autophagy is an intracellular degradation process that is mediated by de novo formation of autophagosomes. Autophagosome formation involves dynamic morphological changes; a disk-shaped membrane cisterna grows, bends to become a cup-shaped ...
Sakai, Y., Tachikawa, M., Mizushima, N., Noboru Mizushima, Masashi Tachikawa, Yuji Sakai, Roland L. Knorr, Knorr, R., Koyama-Honda, I., Ikuko Koyama-Honda   +9 more
core   +1 more source

The Intriguing Life of Autophagosomes [PDF]

International Journal of Molecular Sciences, 2012
Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the ...
Mijaljica, Dalibor, Prescott, Mark, Devenish, Rodney J.   +2 more
openaire   +2 more sources

The Impact of Aging on Macroautophagy in the Pre-ovulatory Mouse Oocyte

Frontiers in Cell and Developmental Biology, 2021
Accompanying the precipitous age-related decline in human female fertility is an increase in the proportion of poor-quality oocytes within the ovary. The macroautophagy pathway, an essential protein degradation mechanism responsible for maintaining cell ...
Alexandra E. Peters, Alexandra E. Peters, Shandelle J. Caban, Shandelle J. Caban, Eileen A. McLaughlin, Eileen A. McLaughlin, Eileen A. McLaughlin, Eileen A. McLaughlin, Shaun D. Roman, Shaun D. Roman, Shaun D. Roman, Elizabeth G. Bromfield, Elizabeth G. Bromfield, Elizabeth G. Bromfield, Brett Nixon, Brett Nixon, Jessie M. Sutherland, Jessie M. Sutherland   +17 more
doaj   +1 more source

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation [PDF]

, 2013
The membrane remodeling events required for autophagosome biogenesis are still poorly understood. Because PX domain proteins mediate membrane remodeling and trafficking, we conducted an imaging-based siRNA screen for autophagosome formation targeting ...
Søreng, Kristiane, Camilla Raiborg, Andreas Brech, Simonsen, Anne, Anne Simonsen, Harald Stenmark, Sven R. Carlsson, Carlsson, Sven R,, Tor Erik Rusten, Karin Håberg, Knævelsrud, Helene, Rasmuson, Fredrik,, Raiborg, Camilla, Neufeld, Thomas P, Brech, Andreas, Helene Knævelsrud, Håberg, Karin,, Carlsson, Sven R, Stenmark, Harald, Knut Liestøl, Liestøl, Knut, Håberg, Karin, Thomas P. Neufeld, Rusten, Tor Erik, Kristiane Søreng, Rasmuson, Fredrik, Fredrik Rasmuson   +26 more
core   +1 more source

Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome–vacuole fusion [PDF]

Journal of Cell Biology, 2018
Autophagy mediates the bulk degradation of cytoplasmic material, particularly during starvation. Upon the induction of autophagy, autophagosomes form a sealed membrane around cargo, fuse with a lytic compartment, and release the cargo for degradation.
Levent Bas, Daniel Papinski, Mariya Licheva, Raffaela Torggler, Sabrina Rohringer, Martina Schuschnig, Claudine Kraft   +6 more
openaire   +4 more sources