Results 21 to 30 of about 67,397 (261)
The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy
Autophagy Reports, 2022 Macroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation ...
Franziska Kriegenburg +7 more
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The Impact of Aging on Macroautophagy in the Pre-ovulatory Mouse Oocyte
Frontiers in Cell and Developmental Biology, 2021 Accompanying the precipitous age-related decline in human female fertility is an increase in the proportion of poor-quality oocytes within the ovary. The macroautophagy pathway, an essential protein degradation mechanism responsible for maintaining cell ...
Alexandra E. Peters +17 more
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The Intriguing Life of Autophagosomes [PDF]
International Journal of Molecular Sciences, 2012 Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the ...
Mijaljica, Dalibor +2 more
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Scaffolding the expansion of autophagosomes [PDF]
Autophagy, 2014 The conjugation of the small ubiquitin (Ub)-like protein Atg8 to autophagic membranes is a key step during the expansion of phagophores. This reaction is driven by 2 interconnected Ub-like conjugation systems. The second system conjugates the Ub-like protein Atg12 to Atg5.
Kaufmann, A., Wollert, T.
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Pharmaceuticals, 2021 Polyphenols are a family of naturally occurring organic compounds, majorly present in fruits, vegetables, and cereals, characterised by multiple phenol units, including flavonoids, tannic acid, and ellagitannin.
James Michael Brimson +6 more
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Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 2021 The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion of FIP200 vesicles, derived from the cis-Golgi, with endosomally derived ...
Kumar, Suresh +21 more
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Communicative & Integrative Biology, 2017 Endoplasmic Reticulum (ER), spreading in the whole cell cytoplasm, is a central player in eukaryotic cell homeostasis, from plants to mammals. Beside crucial functions, such as membrane lipids and proteins synthesis and outward transport, the ER is able ...
Diana Molino +4 more
doaj +1 more source
eLife, 2013 Autophagy is a catabolic process for bulk degradation of cytosolic materials mediated by double-membraned autophagosomes. The membrane determinant to initiate the formation of autophagosomes remains elusive.
Liang Ge +3 more
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Microbiology Spectrum, 2022 Rice blast disease caused by Magnaporthe oryzae is a serious threat to global grain yield and food security. Cti6 is a nuclear protein containing a plant homeodomain (PHD) that is involved in transcriptional regulation in Saccharomyces cerevisiae.
Jing Wang +7 more
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Measuring autophagosome flux [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a proteolytic pathway that is involved in both bulk degradation of cytoplasmic proteins as well as in selective degradation of cytoplasmic organelles. Autophagic flux is often defined as a measure of autophagic degradation activity, and many techniques exist to assess autophagic flux. Although these techniques have generated
Andre du Toit +3 more
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