Results 261 to 270 of about 73,321 (302)

<i>ATG</i>8 and protein ATG8ylation - more than just <i>A</i>nother <i>T</i>a<i>G</i>? [PDF]

Autophagy
Gerth F, Kosol S, Aley N, Agrotis A, Ketteler R.   +4 more
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Targeting UCHL3 attenuates pathological markers in neuronal models of Huntington's disease. [PDF]

Brain
Ishtayeh H, Battistoni E, Pochtar S, McHugh TLM, Tshilenge KT, Rossmiller B, Amer-Sarsour F, Berdichevsky Y, Muchtar N, Weil M, Ellerby LM, Ashkenazi A.   +11 more
europepmc   +1 more source

A Non‐Channel Function of CFTR: Attenuating Mitochondrial Oxidative Stress and Cardiomyocyte Senescence via Stabilization by USP45

Aging Cell, Volume 25, Issue 7, July 2026.
USP45 stabilizes CFTR through deubiquitination, thereby activating PMCA, which inhibits calcium/chloride overload and mitochondrial oxidative stress in senescent cardiomyocytes, ultimately alleviating cardiomyocyte senescence. ABSTRACT Cardiomyocyte senescence drives cardiovascular disease, underscoring the need to define its molecular mechanisms.
Chun Chen, Longtan Jiang, Yuewen Qiu, Chong Liu, Xiao Long, Pengcui Wu, Liang Li, Haixia Xu, Ping Deng, Li Yang, Qiao Jin   +10 more
wiley   +1 more source

Decoding the brain's ATG8 paralog code: LC3-GABARAP specialization at synapses and the astrocyte-neuron interface. [PDF]

Front Cell Dev Biol
Choi H, Lee SM, Lee JA.
europepmc   +1 more source

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter   +3 more
wiley   +1 more source

Integrating network pharmacology and experimental validation to elucidate the mechanism by which 2-Dihydroailanthone induces HCT116 cell death through suppressing autophagy via the AMPK/mTOR pathway. [PDF]

BMC Cancer
An B, Wang J, Li Z, Peng L, Luo X, Zhao X, Shen J, Wang X.   +7 more
europepmc   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, Volume 600, Issue 12, Page 1782-1800, June 2026.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

From organelles to therapy: rethinking combined hepatocellular-cholangiocarcinoma. [PDF]

Front Cell Dev Biol
Zhang T, Li K, Li Q, Gao Q, Du L, Deng J, Cao Z, Guo S, Zhang Z.   +8 more
europepmc   +1 more source

Screening Atg11, a central organizer of yeast selective autophagy, for residues involved in the Atg11-Atg9 interaction. [PDF]

MicroPubl Biol
Sherpa CD, Woghiren P, Leonello E, Abdel-Khalek M, Schuessler BJ, Vermaas JV, Backues SK.   +6 more
europepmc   +1 more source