Results 281 to 290 of about 73,321 (302)
Some of the next articles are maybe not open access.
Nature Reviews Molecular Cell Biology, 2021
Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.
openaire +2 more sources
Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.
openaire +2 more sources
2008
Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
openaire +3 more sources
Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
openaire +3 more sources
AutophagosOMES: identification of autophagosomal cargo in CD4+ T cells by proteomics
Autophagy, 2022Macroautophagy/autophagy, a cellular process that sequesters and breaks down cellular components in the lysosome/vacuole, is important in various events where cell composition undergoes changes. Broadly, autophagy is involved in T cell regulation including maintaining cell homeostasis.
Faris Jafri +3 more
openaire +2 more sources
Actin shapes the autophagosome
Nature Cell Biology, 2015Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional ...
Petter, Holland, Anne, Simonsen
openaire +2 more sources
The origin of the autophagosomal membrane
Nature Cell Biology, 2010Macroautophagy is initiated by the formation of the phagophore (also called the isolation membrane). This membrane can both selectively and non-selectively engulf cytosolic components, grow and close around the sequestered components and then deliver them to a degradative organelle, the lysosome.
Sharon A, Tooze, Tamotsu, Yoshimori
openaire +2 more sources
Protein Trafficking into Autophagosomes
2008The methods described are designed to enable the assignment of an intracellular localization of secretory proteins, either soluble or membrane associated, to later secretory compartments, such as the trans-Golgi network (TGN) or endosome. These two subcellular compartments are closely linked through extensive protein trafficking, in both an anterograde
Andrew, Young, Sharon, Tooze
openaire +2 more sources
Electrostatic maturation of the autophagosome
AutophagyIn macroautophagy, lysosomes fuse with closed autophagosomes but not with unclosed ones. This is achieved, at least in part, by the temporally regulated recruitment of the autophagosomal SNARE STX17 (syntaxin 17) to only mature autophagosomes. However, the molecular mechanism by which STX17 recognizes autophagosomal maturation remains unknown.
Saori Shinoda, Noboru Mizushima
openaire +2 more sources
Fine Structure of the Autophagosome
2008This chapter describes the electron microscopic fine structure of early and late autophagic vacuoles in mammalian cells. Detailed instructions are given for the preparation of cells for conventional electron microscopy and for the identification of autophagic vacuoles by morphology.
openaire +2 more sources