Results 271 to 280 of about 73,321 (302)

SNX-3 confers lysosomal fusion-competence to sustain basal autophagy. [PDF]

Cell Mol Life Sci
Kang Q, Liu Z, Xiang L, Yang S, Yi P, Zhang R.   +5 more
europepmc   +1 more source

The role of autophagy in ocular health: mechanisms, pathologies, and therapeutic strategies. [PDF]

Biol Direct
Huang M, Lin Y, Zhang H, Yuan R, Zeng L, Li S, Yang Q, Gong M, Xiao R, Jia P, Yuan L, Guo Q, Han Z, Xie L.   +13 more
europepmc   +1 more source

Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity. [PDF]

Mol Biol Cell
Theodore CJ, Wagner LH, Campellone KG.
europepmc   +1 more source

Membrane dynamics in autophagosome biogenesis

Journal of Cell Science, 2015
Bilayered phospholipid membranes are vital to the organization of the living cell. Based on fundamental principles of polarity, membranes create borders allowing defined spaces to be encapsulated. This compartmentalization is a prerequisite for the complex functional design of the eukaryotic cell, yielding localities that can differ in composition and ...
Sven R, Carlsson, Anne, Simonsen
openaire   +3 more sources

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Autophagosome Trafficking

2021
Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover of cellular components through engulfing portions of the cytoplasm or organelles and delivering them to the lysosomes/vacuole to be degraded.
Jingjing, Ye, Ming, Zheng
openaire   +2 more sources

Autophagosome Biogenesis Machinery

Journal of Molecular Biology, 2020
We review current knowledge of the process of autophagosome formation with special emphasis on the very early steps: turning on the autophagy pathway, assembling the autophagy machinery, and building the autophagosome. The pathway is remarkably well coordinated spatially and temporally, and it shows broad conservation across species and cell types ...
Simon A. Walker, Nicholas T. Ktistakis
openaire   +2 more sources

Autophagosomes and human diseases

The International Journal of Biochemistry & Cell Biology, 2011
The autophagosome is a double-membrane bound compartment that initiates macroautophagy, a degradative pathway for cytoplasmic material terminating in the lysosomal compartment. The discovery of ATG genes involved in the formation of autophagosomes has greatly increased our understanding of the molecular basis of macroautophagy, and its role in cell ...
Isabelle, Beau, Maryam, Mehrpour, Patrice, Codogno   +2 more
openaire   +2 more sources