A novel autophagy inhibitor, bTBT, disturbs autophagosome formation [PDF]
Autophagy Reports, 2023 Macroautophagy (hereafter, autophagy) is a form of intracellular degradation in which autophagosome formation is systematically coordinated by multiple processes involving numerous autophagy-related gene (ATG) proteins. Autophagy-modulating compounds are
Momoka Chiba +6 more
doaj +2 more sources
Mechanisms of autophagosome formation [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesThe formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis.
Yuko FUJIOKA, Nobuo N. NODA
doaj +2 more sources
An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. [PDF]
PLoS Pathogens, 2009 Group A streptococcus (GAS; Streptococcus pyogenes) is a common pathogen that invades non-phagocytic human cells via endocytosis. Once taken up by cells, it escapes from the endocytic pathway to the cytoplasm, but here it is contained within a membrane ...
Hitomi Yamaguchi +5 more
doaj +3 more sources
Phosphatidylinositol-4-phosphate controls autophagosome formation in Arabidopsis thaliana [PDF]
Nature Communications, 2022 Autophagosomes are specialized vesicles that target and deliver cargo to the lytic vacuole. Here the authors show that plasma-membrane derived lipid phosphatidylinositol-4-phosphate supports the assembly and expansion of autophagosomes in ...
Rodrigo Enrique Gomez +9 more
doaj +2 more sources
Autophagosome formation in relation to the endoplasmic reticulum [PDF]
Journal of Biomedical Science, 2020 Autophagy is a process in which a myriad membrane structures called autophagosomes are formed de novo in a single cell, which deliver the engulfed substrates into lysosomes for degradation.
Yo-hei Yamamoto, Takeshi Noda
doaj +2 more sources
Modeling Membrane Morphological Change during Autophagosome Formation [PDF]
iScience, 2020 Summary: Autophagy is an intracellular degradation process that is mediated by de novo formation of autophagosomes. Autophagosome formation involves dynamic morphological changes; a disk-shaped membrane cisterna grows, bends to become a cup-shaped ...
Yuji Sakai +4 more
doaj +2 more sources
SEC31a‐ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation [PDF]
Advanced ScienceAutophagy plays an important role in determining stem‐cell differentiation. During the osteogenic differentiation of mesenchymal stem cells (MSCs), autophagosome formation is upregulated but the reason is unknown.
Jiaming Nie +9 more
doaj +2 more sources
Local membrane source gathering by p62 body drives autophagosome formation [PDF]
Nature Communications, 2023 Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate substrates for lysosomal degradation during autophagy. Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms ...
Xuezhao Feng +17 more
doaj +2 more sources
In situ structural analysis reveals membrane shape transitions during autophagosome formation. [PDF]
Proc Natl Acad Sci U S A, 2022 Bieber A +10 more
europepmc +5 more sources
Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes [PDF]
Frontiers in Microbiology, 2018 Autophagy is an essential process for cellular metabolism and homeostasis, but also functions as one of innate immune responses against pathogen infection.
Takahiro Kuroki +4 more
doaj +2 more sources