Results 31 to 40 of about 79,616 (304)

Myc inhibition impairs autophagosome formation [PDF]

Human Molecular Genetics, 2013
Autophagy, a major clearance route for many long-lived proteins and organelles, has long been implicated in cancer development. Myc is a proto-oncogene often found to be deregulated in many cancers, and thus is an attractive target for design of cancer therapy.
Toh, P.P.C., Luo, S., Menzies, F.M., Raskó, T., Wanker, E.E., Rubinsztein, D.C.   +5 more
openaire   +3 more sources

Vesicular trafficking and autophagosome formation [PDF]

Cell Death & Differentiation, 2009
The source of the autophagosome membrane, and the formation of the autophagosome remain the most important questions for understanding autophagy. Fundamentally, the process of autophagosome formation is similar between yeast and mammalian cells and many of the proteins involved (called the autophagy-related (Atg) proteins) are known, having been first ...
A, Longatti, S A, Tooze
openaire   +2 more sources

Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. [PDF]

J Biol Chem, 2021
Macroautophagy dysregulation is implicated in multiple neurological disorders, such as Parkinson's disease. While autophagy pathways are heavily researched in heterologous cells and neurons, regulation of autophagy in the astrocyte, the most abundant cell type in the mammalian brain, is less well understood.
Pan PY, Zhu J, Rizvi A, Zhu X, Tanaka H, Dreyfus CF.   +5 more
europepmc   +4 more sources

Atg41/Icy2 regulates autophagosome formation [PDF]

Autophagy, 2015
Macroautophagy (hereafter autophagy) is one of the major degradation systems in eukaryotic cells, and its dysfunction may result in diseases ranging from neurodegeneration to cancer. Although most of the autophagy-related (Atg) proteins that function in this pathway were first identified in yeast, many were subsequently shown to have homologs in higher
Zhiyuan, Yao, Elizabeth, Delorme-Axford, Steven K, Backues, Daniel J, Klionsky   +3 more
openaire   +2 more sources

Scission, a critical step in autophagosome formation. [PDF]

Autophagy, 2020
A key feature of macroautophagy (hereafter autophagy) is the formation of the phagophore, a double-membrane compartment sequestering cargos and finally maturing into a vesicle termed an autophagosome; however, where these membranes originate from is not clear.
Lei Y, Klionsky DJ.
europepmc   +4 more sources

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]

, 2020
Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Arias-Muñoz, Eloisa, Bandau, Susanne, Burgos, Patricia V., Bustamante, Hianara A., Cancino, Jorge, Cerda-Troncoso, Cristóbal, Cereceda, Karina, Cheuquemilla, Yorka, González, Alexis E., Hay, Ronald T., Hernández, Sergio, Kausel, Gudrun, Kerr, Bredford, Mardones, Gonzalo A., Rojas-Fernandez, Alejandro, Soza, Andrea, Valenzuela, Guillermo E.   +16 more
core   +2 more sources

Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes [PDF]

Traffic, 2005
Nutrient deprivation of eukaryotic cells provokes a variety of stress responses, including autophagy. Autophagy is carried out by autophagosomes which sequester cytosolic components and organelles for degradation after fusion with protease‐containing endosomes.
Köchl, Robert, Hu, Xiao Wen, Chan, Edmond Y W, Tooze, Sharon A   +3 more
openaire   +3 more sources

Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation [PDF]

Molecular Biology of the Cell, 2008
Autophagy induced by nutrient depletion is involved in survival during starvation conditions. In addition to starvation-induced autophagy, the yeast Saccharomyces cerevisiae also has a constitutive autophagy-like system, the Cvt pathway. Among 31 autophagy-related (Atg) proteins, the function of Atg17, Atg29, and Atg31 is required specifically for ...
Tomoko Kawamata, Kamada, Yoshiaki, Kabeya, Yukiko, Sekito, Takayuki, Yoshinori Ohsumi   +4 more
openaire   +2 more sources

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]

, 2016
Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto, Gambardella, Lucrezia, Garofalo, Tina, Malorni, Walter, Manganelli, Valeria, Marconi, Matteo, Matarrese, Paola, Misasi, Roberta, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +2 more sources

Ole1, fatty acid desaturase, is required for Atg9 delivery and isolation membrane expansion during autophagy in Saccharomyces cerevisiae

Biology Open, 2017
Macroautophagy, a major degradation pathway of cytoplasmic components, is carried out through formation of a double-membrane structure, the autophagosome. Although the involvement of specific lipid species in the formation process remains largely obscure,
Yuta Ogasawara, Shintaro Kira, Yukio Mukai, Takeshi Noda, Akitsugu Yamamoto   +4 more
doaj   +1 more source