Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes. [PDF]
PLoS ONE, 2016 Autophagy acts as a host-defense system against pathogenic microorganisms such as Group A Streptococcus (GAS). Autophagy is a membrane-mediated degradation system that is regulated by intracellular membrane trafficking regulators, including small GTPase ...
Seiichiro Oda +6 more
doaj +1 more source
Tracking autophagy during proliferation and differentiation of trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Coombs, Graham H. +3 more
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Origin of the Autophagosomal Membrane in Plants
Frontiers in Plant Science, 2016 During autophagy, cargo molecules destined for degradation are sequestrated into a double membrane structure called autophagosome, which subsequently fuses with the vacuole.
Xiaohong Zhuang +3 more
doaj +1 more source
Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]
, 2012 Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso +58 more
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PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. [PDF]
, 2012 Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD).
Beigel, Florian +15 more
core +9 more sources
Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1
Signal Transduction and Targeted Therapy, 2021 Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins, aged or malfunctioning organelles, which is essential for the intracellular homeostasis and prevention of malignant transformation.
Wenchang Xiao +10 more
doaj +1 more source
Recycling endosomes contribute to autophagosome formation [PDF]
Autophagy, 2012 Autophagosome formation is a complex cellular process, which requires major membrane rearrangements leading to the creation of a relatively large double-membrane vesicle that directs its contents to the lysosome for degradation. Although various membrane compartments have been identified as sources for autophagosomal membranes, the molecular mechanism ...
Andrea, Longatti, Sharon A, Tooze
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2022 A growing body of evidence suggests that neutrophil extracellular traps (NETs) critically contribute to the development of atherosclerosis. However, the detailed mechanism of how NETs promote atherogenesis remains unknown.
Masataka Sano +8 more
doaj +1 more source
VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. [PDF]
, 2015 Lysosomes are classically viewed as vesicular structures to which cargos are delivered for degradation. Here, we identify a network of dynamic, tubular lysosomes that extends throughout Drosophila muscle, in vivo. Live imaging reveals that autophagosomes
Davis, Graeme W +4 more
core +3 more sources