Results 11 to 20 of about 72,795 (291)
Cells, 2023 Autophagy–the lysosomal degradation of cytoplasm–plays a central role in cellular homeostasis and protects cells from potentially harmful agents that may accumulate in the cytoplasm, including pathogens, protein aggregates, and dysfunctional organelles. This process is initiated by the formation of a phagophore membrane, which wraps around a portion of
Yan Zhen, Harald Stenmark
openaire +4 more sources
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 2021 The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion of FIP200 vesicles, derived from the cis-Golgi, with endosomally derived ...
Kumar, Suresh +21 more
openaire +5 more sources
Journal of Molecular Biology, 2020 Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes. The process starts with the capture of unnecessary material into autophagosomes, which is followed by autophagosome-lysosome fusion to generate autolysosomes that degrade the ...
Lőrincz, Péter, Juhász, Gábor
openaire +4 more sources
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C
Frontiers in Cellular Neuroscience, 2021 Niemann-Pick type C (NPC) disease, sometimes called childhood Alzheimer’s, is a rare neurovisceral lipid storage disease with progressive neurodegeneration leading to premature death.
Lien Van Hoecke +30 more
doaj +1 more source
Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy
Frontiers in Pharmacology, 2021 Autophagy is the major catabolic pathway involved in removing and recycling damaged macromolecules and organelles and several evidences suggest that dysfunctions of this pathway contribute to the onset and progression of central and peripheral ...
Annagrazia Adornetto +5 more
doaj +1 more source
Measuring autophagosome flux [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a proteolytic pathway that is involved in both bulk degradation of cytoplasmic proteins as well as in selective degradation of cytoplasmic organelles. Autophagic flux is often defined as a measure of autophagic degradation activity, and many techniques exist to assess autophagic flux. Although these techniques have generated
Andre du Toit +3 more
openaire +2 more sources
Cells, 2022 People with human immunodeficiency virus-1 (PLWH) experience high rates of HIV-1-associated neurocognitive disorders (HANDs); clinical symptoms range from being asymptomatic to experiencing HIV-associated dementia.
Peter W. Halcrow +5 more
doaj +1 more source
Учёные записки Казанского университета: Серия Естественные науки, 2020 Autophagy is a highly conserved process of intracellular degradation of damaged, oxidized or excess macromolecules and organelles in eukaryotic cells. Under optimal conditions, the baseline level of autophagy is low.
A.B. Mazina +5 more
doaj +1 more source
Morphodynamics of non-canonical autophagic structures in Neurospora crassa
mSphere, 2023 Autophagy is a major pathway for unspooling cytoplasmic constituents and recycling them. Here, we investigate autophagy in Neurospora crassa, a close ascomycete relative to the model yeast Saccharomyces cerevisiae.
Alberto Rivetta +5 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2023 INTRODUCTION: High-fructose, high-fat diet consumption (HFHF) is one of the primary causes of non-alcoholic fatty liver disease (NAFLD), which is due to impaired beta-oxidation or apolipoprotein secretion by hepatocytes.
Sara Adel Hosny +3 more
doaj +1 more source