Results 251 to 260 of about 72,795 (291)

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

IRF7 drives macrophages to kill bacteria and improves septic outcomes via autophagy. [PDF]

JCI Insight
Chen G, Li K, Luo H, Zhao L, Jiang Y.
europepmc   +1 more source

Cardiomyocyte‐Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING‐Mediated Inflammation

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
USP20 directly binds to STING and promotes the degradation of STING through the autophagy pathway by deubiquitinating p62 via its active site C154, thereby alleviating myocardial inflammation and improving ventricular remodeling and heart failure induced by diabetes. ABSTRACT Although extensive clinical and basic research has been conducted on diabetic
Yixin Zhou, Miaomiao Ying, Baozhen Qi, Yunxuan Chen, Weihong Lin, Chunwu Zhang, Jiahui Lin, Yucong Zhang, Zexin Yang, Ziyi Huang, Jun Wu, Xueli Cai, Weijian Huang, Zhouqing Huang, Zhenfeng Cheng, Shanshan Dai   +15 more
wiley   +1 more source

Functional analyses and integrated mechanisms of cellular destruction by L-amino acid oxidase. [PDF]

Cell Death Dis
Prak K, Luft C, Tsefou E, Chávez-Olórtegui C, Kriston-Vizi J, Ketteler R, Braga VMM.   +6 more
europepmc   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, Volume 13, Issue 8, 9 February 2026.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Tunneling Nanotube-Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury. [PDF]

Adv Sci (Weinh)
Wang T, Wang L, Sun J, Chen Y, Ali W, Ma Y, Song R, Tong X, Zhu J, Yuan Y, Gu J, Bian J, Liu Z, Zou H.   +13 more
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Astragalus polysaccharide alleviates diabetic nephropathy via SIRT1-dependent activation of FOXO3a/BNIP3 pathway to enhance podocyte autophagy. [PDF]

Sci Rep
Guo M, Dai Y, Zhuang X.
europepmc   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

A TOM1 variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunity.

Dis Model Mech
Lång HKM, Roach TG, Hölttä M, Keskitalo S, Varjosalo M, Heiskanen K, Collins MV, Seppänen MRJ, Capelluto DGS, Ikonen E, Ryhänen SJ.   +10 more
europepmc   +1 more source