Results 271 to 280 of about 58,150 (299)

Actin shapes the autophagosome

Nature Cell Biology, 2015
Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional ...
Petter, Holland, Anne, Simonsen
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The origin of the autophagosomal membrane

Nature Cell Biology, 2010
Macroautophagy is initiated by the formation of the phagophore (also called the isolation membrane). This membrane can both selectively and non-selectively engulf cytosolic components, grow and close around the sequestered components and then deliver them to a degradative organelle, the lysosome.
Sharon A, Tooze, Tamotsu, Yoshimori
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Protein Trafficking into Autophagosomes

2008
The methods described are designed to enable the assignment of an intracellular localization of secretory proteins, either soluble or membrane associated, to later secretory compartments, such as the trans-Golgi network (TGN) or endosome. These two subcellular compartments are closely linked through extensive protein trafficking, in both an anterograde
Andrew, Young, Sharon, Tooze
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Electrostatic maturation of the autophagosome

Autophagy
In macroautophagy, lysosomes fuse with closed autophagosomes but not with unclosed ones. This is achieved, at least in part, by the temporally regulated recruitment of the autophagosomal SNARE STX17 (syntaxin 17) to only mature autophagosomes. However, the molecular mechanism by which STX17 recognizes autophagosomal maturation remains unknown.
Saori Shinoda, Noboru Mizushima
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Membrane dynamics in autophagosome biogenesis

Journal of Cell Science, 2015
Bilayered phospholipid membranes are vital to the organization of the living cell. Based on fundamental principles of polarity, membranes create borders allowing defined spaces to be encapsulated. This compartmentalization is a prerequisite for the complex functional design of the eukaryotic cell, yielding localities that can differ in composition and ...
Sven R, Carlsson, Anne, Simonsen
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Fine Structure of the Autophagosome

2008
This chapter describes the electron microscopic fine structure of early and late autophagic vacuoles in mammalian cells. Detailed instructions are given for the preparation of cells for conventional electron microscopy and for the identification of autophagic vacuoles by morphology.
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ATG9 vesicles comprise the seed membrane of mammalian autophagosomes

Journal of Cell Biology, 2023
Taryn J Olivas, Yumei Wu, Shenliang Yu
exaly  

Autophagosomes need calcium

Nature Structural & Molecular Biology, 2022
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Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases

Journal of Cell Biology, 2023
Sydney E Cason, Erika L F Holzbaur
exaly  

Myosin II moves in on autophagosomes

Nature Reviews Molecular Cell Biology, 2011
Katharine H Wrighton, Wrighton Katharine H   +1 more
exaly