Results 261 to 270 of about 58,150 (299)
Decoding the brain's ATG8 paralog code: LC3-GABARAP specialization at synapses and the astrocyte-neuron interface. [PDF]
Front Cell Dev BiolChoi H, Lee SM, Lee JA.
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2021
Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover of cellular components through engulfing portions of the cytoplasm or organelles and delivering them to the lysosomes/vacuole to be degraded.
Jingjing, Ye, Ming, Zheng
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Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover of cellular components through engulfing portions of the cytoplasm or organelles and delivering them to the lysosomes/vacuole to be degraded.
Jingjing, Ye, Ming, Zheng
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Hepatitis C Virus Induces the Localization of Lipid Rafts to Autophagosomes for Its RNA Replication
Journal of Virology, 2017 Autophagy plays important roles in maintaining cellular homeostasis. It uses double- or multiple-membrane vesicles termed autophagosomes to remove protein aggregates and damaged organelles from the cytoplasm for recycling.
Linya Wang +2 more
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Autophagosome Biogenesis Machinery
Journal of Molecular Biology, 2020We review current knowledge of the process of autophagosome formation with special emphasis on the very early steps: turning on the autophagy pathway, assembling the autophagy machinery, and building the autophagosome. The pathway is remarkably well coordinated spatially and temporally, and it shows broad conservation across species and cell types ...
Simon A. Walker, Nicholas T. Ktistakis
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MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons [PDF]
Autophagy, 2014 Autophagy is a spatially regulated process in axons; autophagosomes form preferentially in the distal axon tip then move actively and processively toward the cell body.
Meng-Meng Fu, Erika L F Holzbaur
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The many uses of autophagosomes [PDF]
Autophagy, 2013 Autophagy has emerged as a significant innate immune response to pathogens. Typically, autophagosomes deliver their contents to lysosomes for degradation. Some pathogens such as Salmonella enterica serovar Typhimurium succumb to autophagy and are transported to lysosomes for degradation.
Amal O Amer
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Autophagosomes and human diseases
The International Journal of Biochemistry & Cell Biology, 2011The autophagosome is a double-membrane bound compartment that initiates macroautophagy, a degradative pathway for cytoplasmic material terminating in the lysosomal compartment. The discovery of ATG genes involved in the formation of autophagosomes has greatly increased our understanding of the molecular basis of macroautophagy, and its role in cell ...
Isabelle, Beau +2 more
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Nature Reviews Molecular Cell Biology, 2021
Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.
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Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.
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2008
Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
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Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
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AutophagosOMES: identification of autophagosomal cargo in CD4+ T cells by proteomics
Autophagy, 2022Macroautophagy/autophagy, a cellular process that sequesters and breaks down cellular components in the lysosome/vacuole, is important in various events where cell composition undergoes changes. Broadly, autophagy is involved in T cell regulation including maintaining cell homeostasis.
Faris Jafri +3 more
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