Results 271 to 280 of about 72,795 (291)
Npl3 is required for efficient autophagosome-vacuole fusion. [PDF]
AutophagyYin Z, Zhang Z, Liu X, Klionsky DJ.
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Advances in the basic function of the small GTPase SAR1B and its regulatory role in the biological behavior of tumor cells (Review). [PDF]
Mol Clin OncolYang Q, Huang G, Lu C, Lei Z, Lu H.
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Maintenance and Decline of Neuronal Lysosomal Function in Aging. [PDF]
CellsZhong R, Richardson CE.
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Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant UBB<sup>+1</sup>. [PDF]
Proc Natl Acad Sci U S AWagh AR, Glickman MH.
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2021
Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover of cellular components through engulfing portions of the cytoplasm or organelles and delivering them to the lysosomes/vacuole to be degraded.
Jingjing, Ye, Ming, Zheng
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Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover of cellular components through engulfing portions of the cytoplasm or organelles and delivering them to the lysosomes/vacuole to be degraded.
Jingjing, Ye, Ming, Zheng
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Autophagosome Biogenesis Machinery
Journal of Molecular Biology, 2020We review current knowledge of the process of autophagosome formation with special emphasis on the very early steps: turning on the autophagy pathway, assembling the autophagy machinery, and building the autophagosome. The pathway is remarkably well coordinated spatially and temporally, and it shows broad conservation across species and cell types ...
Simon A. Walker, Nicholas T. Ktistakis
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Nature Reviews Molecular Cell Biology, 2021
Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.
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Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.
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Autophagosomes and human diseases
The International Journal of Biochemistry & Cell Biology, 2011The autophagosome is a double-membrane bound compartment that initiates macroautophagy, a degradative pathway for cytoplasmic material terminating in the lysosomal compartment. The discovery of ATG genes involved in the formation of autophagosomes has greatly increased our understanding of the molecular basis of macroautophagy, and its role in cell ...
Isabelle, Beau +2 more
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Mechanisms governing autophagosome biogenesis
Nature Reviews Molecular Cell Biology, 2020Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf a wide range of intracellular material and transport this autophagic cargo to lysosomes (or vacuoles in yeasts and plants) for subsequent degradation. Autophagosome biogenesis responds to a plethora of signals and involves unique and dynamic membrane processes ...
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Actin shapes the autophagosome
Nature Cell Biology, 2015Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional ...
Petter, Holland, Anne, Simonsen
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