Results 31 to 40 of about 72,795 (291)

Molecular regulation of autophagosome formation [PDF]

Biochemical Society Transactions, 2022
Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative disorders.
Hu, Yan, Reggiori, Fulvio
openaire   +2 more sources

The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]

, 2015
This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara, FAGGIONI, Alberto, FARINA, Antonella, Filardi, M, GONNELLA, ROBERTA, GRANATO, Marisa, SANTARELLI, Roberta, TORRISI, Maria Rosaria   +7 more
core   +1 more source

Herpesvirus and Autophagy: “All Right, Everybody Be Cool, This Is a Robbery!”

Viruses, 2017
Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis.
Marion Lussignol, Audrey Esclatine
doaj   +1 more source

ROOT HAIR DEFECTIVE3 Is a Receptor for Selective Autophagy of the Endoplasmic Reticulum in Arabidopsis

Frontiers in Plant Science, 2022
ROOT HAIR DEFECTIVE3 (RHD3) is a plant member of atlastin GTPases, which belong to an evolutionally conserved family of proteins that mediate the homotypic fusion of the endoplasmic reticulum (ER).
Jiaqi Sun, Weina Wang, Huanquan Zheng
doaj   +1 more source

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor [PDF]

, 2016
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds
Altschul, Bassham, Baxt, Berrow, Birgisdottir, Boyle, Bozkurt, Bozkurt, Bozkurt, Caillaud, Chaparro-Garcia, Choy, Dagdas, Fisher, Geldner, Hanamata, He, Huang, Ivanov, Kalvari, Karimi, Kumar, Kwon, Lamb, Larkin, Lenz, Li, Lipka, Liu, Lv, Morgan, Mostowy, Oh, Patel, Petre, Randow, Randow, Saunders, Segonzac, Shintani, Song, Stolz, Svenning, Teh, Vanhee, Wang, Win, Yoshimoto, Zientara-Rytter   +48 more
core   +2 more sources

LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. [PDF]

, 2019
During autophagy, actin filament networks move and remodel cellular membranes to form autophagosomes that enclose and metabolize cytoplasmic contents. Two actin regulators, WHAMM and JMY, participate in autophagosome formation, but the signals linking ...
Axe, Cooper, Coutts, Coutts, Coyle, Dayel, Demonacos, Firat-Karalar, Graef, Hu, Jahreiss, Kaiser, Kast, Klionsky, Koronakis, Li, Mathiowetz, Mi, Okrut, Padrick, Padrick, Palmgren, Pankiv, Pankiv, Papinski, Quinlan, Quinlan, R. Dyche Mullins, Ran, Rohatgi, Rohatgi, Schlüter, Shibutani, Shikama, Sun, Urbanek, Welch, Xiaohua Hu, Yamamoto, Zhao, Zuchero   +40 more
core   +2 more sources

Autophagosomes Defeat Ferroptosis by Decreasing Generation and Increasing Discharge of Free Fe2+ in Skin Repair Cells to Accelerate Diabetic Wound Healing

Advanced Science, 2023
Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting potential therapeutic strategies targeting ferroptosis.
Shengnan Cui, Xi Liu, Yong Liu, Wenzhi Hu, Kui Ma, Qilin Huang, Ziqiang Chu, Lige Tian, Sheng Meng, Jianlong Su, Wenhua Zhang, Haihong Li, Xiaobing Fu, Cuiping Zhang   +13 more
doaj   +1 more source

Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans

eLife, 2022
Autophagosomes are double-membrane intracellular vesicles that degrade protein aggregates, intracellular organelles, and other cellular components.
Omar Peña-Ramos, Lucia Chiao, Xianghua Liu, Xiaomeng Yu, Tianyou Yao, Henry He, Zheng Zhou   +6 more
doaj   +1 more source

The proppin Bcas3 and its interactor KinkyA localize to the early phagophore and regulate autophagy [PDF]

, 2021
To resolve the signaling mechanisms that mediate the starvation-induced processes of Dictyostelium sporulation and encystation, we performed insertional mutagenesis on cells harboring an mRFP-tagged spore gene.
Schaap, Pauline, Yamada, Yoko
core   +2 more sources

Quantitative 3D correlative light and electron microscopy of organelle association during autophagy

Cell Structure and Function, 2022
In macroautophagy, disk-shaped double-membrane structures called phagophores elongate to form cup-shaped structures, becoming autophagosomes upon closure. These autophagosomes then fuse with lysosomes to become autolysosomes and degrade engulfed material.
Satoru Takahashi, Chieko Saito, Ikuko Koyama-Honda, Noboru Mizushima   +3 more
doaj   +1 more source