The Multivesicular Body and Autophagosome Pathways in Plants
Frontiers in Plant Science, 2018 In eukaryotic cells, the endomembrane system consists of multiple membrane-bound organelles, which play essential roles in the precise transportation of various cargo proteins.
Yong Cui +10 more
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Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes [PDF]
Traffic, 2005 Nutrient deprivation of eukaryotic cells provokes a variety of stress responses, including autophagy. Autophagy is carried out by autophagosomes which sequester cytosolic components and organelles for degradation after fusion with protease‐containing endosomes.
Köchl, Robert +3 more
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The Alternaria alternata Mip1/RAPTOR Mediates Virulence by Regulating Toxin Production and Autophagy
Molecular Plant-Microbe InteractionsThe necrotrophic pathogen Alternaria alternata produces a host-selective toxin to attack its host plants. This study characterized the crucial function of the Mip1/RAPTOR ortholog (AaMip1) in toxin production and autophagy formation.
Yu-Ling Huang +2 more
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HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication. [PDF]
PLoS Pathogens, 2017 Hepatitis C virus (HCV) induces autophagy to promote its replication, including its RNA replication, which can take place on double-membrane vesicles known as autophagosomes.
Linya Wang +4 more
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Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation [PDF]
Molecular Biology of the Cell, 2008 Autophagy induced by nutrient depletion is involved in survival during starvation conditions. In addition to starvation-induced autophagy, the yeast Saccharomyces cerevisiae also has a constitutive autophagy-like system, the Cvt pathway. Among 31 autophagy-related (Atg) proteins, the function of Atg17, Atg29, and Atg31 is required specifically for ...
Tomoko Kawamata +4 more
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PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells
International Journal of Nanomedicine, 2020 Jie Gao,1,2,* Xiaohan Chen,1,* Tianjun Ma,1,* Bin He,1 Peng Li,1 Yucheng Zhao,1 Yuejin Ma,1 Jianhua Zhuang,1 You Yin1 1Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People’s Republic of China ...
Gao J +8 more
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Comprehensive proteomic analysis of autophagosomes derived from Leishmania-infected macrophages.
PLoS ONE, 2023 Recently, autophagy has been implicated as a host defense mechanism against intracellular pathogens. On the other hand, certain intracellular pathogens such as Leishmania can manipulate the host's autophagy to promote their survival.
Devki Nandan +5 more
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The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. [PDF]
, 2013 Autophagy is a catabolic pathway typically induced by nutrient starvation to recycle amino acids, but can also function in removing damaged organelles. In addition, this pathway plays a key role in eukaryotic development. To date, not much is known about
Bunnik, Evelien M +9 more
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Connexins modulate autophagosome biogenesis [PDF]
Nature Cell Biology, 2014 The plasma membrane contributes to the formation of autophagosomes, the double-membrane vesicles that sequester cytosolic cargo and deliver it to lysosomes for degradation during autophagy. In this study, we have identified a regulatory role for connexins (Cx), the main components of plasma membrane gap junctions, in autophagosome formation.
Bejarano, Eloy +5 more
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HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. [PDF]
PLoS Pathogens, 2015 Hepatitis C virus (HCV) induces autophagy to enhance its replication. However, how HCV regulates the autophagic pathway remains largely unclear. In this report, we demonstrated that HCV infection could induce the expression of Rubicon and UVRAG, which ...
Linya Wang +2 more
doaj +1 more source