Results 81 to 90 of about 72,795 (291)

Coronavirus NSP6 restricts autophagosome expansion [PDF]

Autophagy, 2014
Autophagy is a cellular response to starvation that generates autophagosomes to carry long-lived proteins and cellular organelles to lysosomes for degradation. Activation of autophagy by viruses can provide an innate defense against infection, and for (+) strand RNA viruses autophagosomes can facilitate assembly of replicase proteins.
Cottam, Eleanor, Whelband, Matthew, Wileman, Tom   +2 more
openaire   +3 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress [PDF]

, 2019
York University ...
Jahng, James Won Suk, Pantopoulos, Kostas, Song, Erfei, Sung, Hye Kyoung, Sweeney, Gary   +4 more
core   +2 more sources

Autophagosome closure requires membrane scission [PDF]

Autophagy, 2015
During the intracellular process of macroautophagy (hereafter autophagy), a membrane-bound organelle, the autophagosome, is generated de novo. The remodeling of the autophagic membrane during the life cycle of the organelle is a complex multistep process and involves several changes in the topology of the autophagic membrane.
Knorr, R., Lipowsky, R. ; https://orcid.org/0000-0001-8417-8567, Dimova, R. ; https://orcid.org/0000-0002-3872-8502   +2 more
openaire   +4 more sources

Phospholipid imbalance impairs autophagosome completion

The EMBO Journal, 2022
AbstractAutophagy, a conserved eukaryotic intracellular catabolic pathway, maintains cell homeostasis by lysosomal degradation of cytosolic material engulfed in double membrane vesicles termed autophagosomes, which form upon sealing of single‐membrane cisternae called phagophores.
Alexandra Polyansky, Oren Shatz, Milana Fraiberg, Eyal Shimoni, Tali Dadosh, Muriel Mari, Fulvio M Reggiori, Chao Qin, Xianlin Han, Zvulun Elazar   +9 more
openaire   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Phosphatidylinositol-4-phosphate controls autophagosome formation in Arabidopsis thaliana

Nature Communications, 2022
Autophagosomes are specialized vesicles that target and deliver cargo to the lytic vacuole. Here the authors show that plasma-membrane derived lipid phosphatidylinositol-4-phosphate supports the assembly and expansion of autophagosomes in ...
Rodrigo Enrique Gomez, Clément Chambaud, Josselin Lupette, Julie Castets, Stéphanie Pascal, Lysiane Brocard, Lise Noack, Yvon Jaillais, Jérôme Joubès, Amélie Bernard   +9 more
doaj   +1 more source

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila [PDF]

, 2013
During autophagy, phagophores capture portions of cytoplasm and form double-membrane autophagosomes to deliver cargo for lysosomal degradation. How autophagosomes gain competence to fuse with late endosomes and lysosomes is not known.
Atlashkin, Attila L. Kovács, Axe, Barth, Berry, Bjørkøy, Dilcher, Fader, Filimonenko, Furuta, Gábor Juhász, Hamasaki, Hara, Hong, Ishihara, Itakura, Juhász, Juhász, Karolina Pircs, Kata Varga, Kimura, Komatsu, Krisztina Hegedűs, Lu, Manuéla Kárpáti, Mizushima, Moreau, Nair, Ohashi, Pircs, Péter Nagy, Renna, Rusten, Simonsen, Steegmaier, Szabolcs Takáts, Tooze, Velikkakath, Ágnes Varga   +38 more
core   +1 more source

Autophagosome Maturation and Fusion

Journal of Molecular Biology, 2017
Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related ...
Reggiori, Fulvio, Ungermann, Christian
openaire   +3 more sources