Results 1 to 10 of about 449,405 (356)

Autophagy and autophagy-related pathways in cancer [PDF]

open access: yesNature Reviews Molecular Cell Biology, 2023
Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates the delivery of various cellular cargoes to lysosomes for degradation and ...
, Kevin M Ryan
exaly   +6 more sources

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death [PDF]

open access: bronzeJournal of Cell Biology, 2005
Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such aggregates.
Geir Bjørkøy   +7 more
openalex   +2 more sources

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

open access: yesNature, 2015
Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains ...
Michael Lazarou   +2 more
exaly   +2 more sources

Autophagy in immunity and inflammation

open access: yesNature, 2011
Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation.
Beth Levine   +2 more
exaly   +2 more sources

Salinomycin Triggers Human Colorectal Cancer HCT116 Cell Death by Targeting Unfolded Protein Responses and Autophagy Pathways [PDF]

open access: yesIranian Journal of Colorectal Research, 2023
Background: Autophagy and the unfolded protein response (UPR) are important pathways in colorectal tumorigenesis and drug resistance, rendering them as potential therapeutic targets for treating this cancer.
Mozhdeh Zamani   +3 more
doaj   +1 more source

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

open access: yesAutophagy, 2021
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field.
D. Klionsky   +499 more
semanticscholar   +1 more source

Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target

open access: yesJournal of Immunology Research, 2023
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment
Hui-Yuan Li   +8 more
doaj   +1 more source

Copper metabolism in cell death and autophagy

open access: yesAutophagy, 2023
Copper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as ...
Qian Xue   +5 more
semanticscholar   +1 more source

Targeting autophagy in cancer

open access: yesNature Reviews Cancer, 2017
Jean M Mulcahy Levy, Christina G Towers
exaly   +2 more sources

hUC-MSC transplantation therapy effects on lupus-prone MRL/lpr mice at early disease stages

open access: yesStem Cell Research & Therapy, 2023
Background The efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in treating systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials.
Fengbiao Guo   +13 more
doaj   +1 more source

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